Numerical simulation

In the poster, you see pressure signals obtained from in silico modelling in different conditions, i.e. in a compliant (healthy) and stiff (aged) blood vessel.  The picture shows P₀ (blue), which is the pressure wave over time measured close to the beginning of a tube, while P₁ (orange) is the pressure measured further down the vessel, assuming a cylindrical elastic tube set-up. The left picture corresponds to an aged or diseased blood vessel with a Young modulus of 2.5 ∙10⁶ dyn·cm⁻² . The right graph shows a healthy blood vessel with a Young modulus of 0.5 ∙10⁶ dyn·cm⁻². The Young modulus represents the stiffness of the vessel and has been correlated to arterial ageing and cardiovascular disease, such as arterial calcification.  

Mathematical modelling and numerical simulation help to obtain insight in the relation between wall parameters such as the Young’s modulus and pulse wave behavior. Moreover, increased pulse wave velocity (PWV) as well as deviation in the morphology are risk factors for cardiovascular disease. As such, mathematical models provide a useful tool for safety pharmacologist to better understand the possible impact of drug-induced changes in hemodynamic parameters and how these translate into clinical risk depending on patient-specific characteristics.