(Photo)electrochemical detection of miRNAs
Circulating amounts of non-coding microRNA (miRNA) have been shown to have a biological impact and to be clinically associated with cancer and are now seen as a new class of biomarkers that will allow earlier and more accurate diagnosis. The objective of INFORM is to develop an innovative electrochemical multiplex biosensor for detection and quantification of a panel of clinically relevant circulating miRNAs in intermediate-risk prostate cancer (PCa) patients that will be submitted to potentially curative surgery.
The biosensor will rely on the selectivity of the sandwich assays and on the sensitivity of the photoelectrochemical detection to quantify, at the sub-fM level, circulating miRNAs that are associated with PCa. The quantification of these overexpressed miRNAs will lead to a better overall management of the disease and allow for a more informed decision by the medical doctor, providing personalised medicine.
