Combination electrochemistry & LC-MS/MS
An in-depth understanding of the electrochemical oxidation and reduction mechanisms is crucial for fully exploiting electrochemical behaviour of low molecular weight molecules. Therefore, in A-Sense Lab we combine information obtained from amperometric and voltammetric measurements with the identification of the formed oxidation/reduction products by high resolution LC-MS/MS (Toxicological Centre, UAntwerp). This allows us insight in the electrochemical and chemical reaction occurring at the electrodes and results into a detailed electrochemical mechanism. As an added bonus, the identified products can mimic the formation of potential oxidative metabolites that could occur in a living organism.
Key publication:
- Cephalosporin Antibiotics: Electrochemical Fingerprints and Core Structure Reactions Investigated by LC–MS/MS, N. Sleegers, A. van Nuijs, M. van den Berg and K. De Wael Analytical Chemistry 91(3) (2019) 2035-2041