The term Cognitive Genetics was introduced to bridge the concepts of genetics and cognitive processes in the first decade of the 21st century. This relatively novel branch of genetics studies the influence of genetic variation on cognition and central nervous system disorders.
Our mission is to identify genetic causes of cognitive disorders and to study the molecular defects in order to eventually develop rational therapy.
Embedding
Our research group Cognitive Genetics is part of the research cluster Medical Genetics of the Faculty of Pharmaceutical, Biomedical and Veterinary Sciences of the University of Antwerp. The research cluster, in combination with diagnostic and clinical units forms the Center of Medical Genetics. We are part of the University of Antwerp research excellence center GENOmics in MEDicine (GENOMED), that was recently awarded a prestigious Methusalem grant. Our group is also a founding member of the expertise technology consortium Precision Medicine Technologies (PreMeT) for logistic support of our industrial collaborations.
NGS data analysis suite
Customised microarray and NGS data analysis tools
MicroArray data analysis and interpretation
Phenotype information
ADNP
FWO - WOG
GABAergic abnormalities in the fragile X syndrome. European Journal of Paediatric Neurology, 2020

Aberrant Function of the C-Terminal Tail of HIST1H1E Accelerates Cellular Senescence and Causes Premature Aging. American Journal of Human Genetics, 2019

Single-Cell and Neuronal Network Alterations in an In Vitro Model of Fragile X Syndrome, Cerebral Cortex, 2019

Clinical presentation of a complex neurodevelopmental disorder caused by mutations in ADNP. Biological Psychiatry, 2019

Mutations in ADNP affect expression and subcellular localization of the protein. Cell Cycle, 2018

Fragile X syndrome: from Genetics to Targeted treatment. Willemsen & Kooy, eds. Academic Press, 2017

A randomized double-blind, placebo-controlled trial of ganaxolone in childrenand adolescents with fragile X syndrome. Journal of Neurodevelopmental Disorders, 2017

Behavioural characterization of AnkyrinG deficient mice, a model for ANK3 related disorders. Behavioural Brain Research. 328: 218-226, 2017

The GABA(A) Receptor as a Therapeutic Target for Neurodevelopmental disorders. Neuron 86:1119–1130, 2015
