Poster and oral presentations | Medical Biochemistry

21st Forum of Pharmaceutical Sciences, organised by the Belgian Society of Pharmaceutical Sciences | April 27-28, 2023 | Blankenberge, Belgium

M. Florindo Espadinha, J. De Loose, S. Benramdane, S. Corthaut, P. Van Wielendaele, Y. Sterckx, I. De Meester, P. Van Der Veken. DPP8/9 Degradation by Proteolysis-Targeting Chimeras (PROTACs). (Oral presentation)

Netherlands Society on Biomolecular Modelling Fall Meeting | October 27, 2022 | Ixelles, Belgium

L. Boeykens, L. De Vocht, S. Das, O. Silvie, Y. Sterckx. Structure-function relationship of the malaria sporozoite 6Cys proteins. (Poster presentation)

3rd International Caparica Conference on Leishmaniasis | October 24-26, 2022 | Lisbon, Portugal

E. Wuyts*, S. Wyllie, V. Postis, M. De Rycker, M. A. Domagalska, J. Dujardin, G.Caljon, Y. G.J. Sterckx. Molecular basis for the potency and selectivity of TCMDC-143345, a promising lead for the development of novel anti-leishmanial drugs. Caparica. (Poster and shotgun presentation)

*Awarded a poster award.

Gordon Research Conference: Proteolytic Enzymes and Their Inhibitors | June 6-9, 2022 | Lucca, Italy

J. De Loose, K. Mertens, Y. Van Rymenant, K. Claesen, S. Thys, I. Pintelon, Y. Sterckx, P. Van Der Veken, I. De Meester. Unveiling DPP9 and CARD8 expression in primary human dendritic cells. (Oral and poster presentation)

Annual scientific meeting of the Belgian Society of Parasitology and Protistology | November 30, 2021 | Antwerp, Belgium

R. Geens, J. Stanisich, S. Magez, H. De Winter, P. Van Wielendaele, F. Sobott, R. Amino, A.N. Volkov, P. Tompa, Y.G.-J. Sterckx. Investigating the structure-function relationship of the malaria parasite circumsporozoite protein. (Oral presentation)

Research Day - Faculty of Pharmaceutical, Biomedical and Veterinary Sciences | October 29, 2021 | Antwerp, Belgium

R. Geens, J. Stanisich, S. Magez, P. Van Wielendaele, F. Sobott, R. Amino, A.N. Volkov, P. Tompa, Y.G.-J. Sterckx. Investigating the structure-function relationship of the malaria parasite circumsporozoite protein. (Oral presentation)

American Society for Biochemistry and Molecular Biology, Conference Serine proteases in pericellular proteolysis and signaling | October 28-30, 2021 | Virtual

Y. Van Rymenant*, M. Tanc, R. Van Elzen, A. Bracke, O. De Wever, A.M. Lambeir, M. Kockx, P. Van Der Veken, I. De Meester. Design and characterization of fluorescent Activity-based probes for imaging fibroblast activation protein (FAP) activity in the tumor microenvironment. (Oral presentation)

*Awarded a Flash Talk Award

4th European Congress on Thrombosis and Haemostasis (ECTH2021) | October 14-15, 2021 | Genth, Belgium

K. Claesen*, Y. Sim, A. Bracke, M. De bruyn, E. De Hert, G. Vliegen, A. Hotterbeekx, A. Vujkovic, F. De Winter, E. Vlieghe, K. Vercauteren, S. Kumar-Singh, I. De Meester, D. Hendriks. Evaluation of the carboxypeptidase U (CPU, TAFIa, CPB2) system in patients with SARS-CoV-2 infection. (Poster presentation)

*Awarded a Poster Award

XXIX ISTH Congress and 66th Annual SSC meeting | July 17-21, 2021 | Virtual

K. Claesen, K. Hermans, L. Roth, JC. Mertens, I. De Meester, GRY. De Meyer, D. Hendriks. Downregulation of the procarboxypeptidase U (proCPU, TAFI, proCPB2) system in ApoE-/-Fbn1C1039G+/- mice is a non-lipid related pleiotropic effect of statin therapy. (Poster presentation)

Poster and oral presentations <2021

EMBO Chemical Biology | September 3-5, 2020 | Virtual

Y. Van Rymenant, M. Tanc, R. Van Elzen, A. Bracke, M. Kockx, P. Van Der Veken, I. De Meester. Development of fluorescent Activity-based probes for detection of fibroblast activation protein (FAP) activity in the tumor microenvironment. (Poster presentation)

GRS and GRC on Plasminogen Activation and Extracellular Proteolysis | February 9-14, 2020 | Ventura, United States

JC. Mertens*, D. Leenaerts, W. Boisseau, L. Di Meglio, K. Claesen, S. Loyau, A.M. Lambeir, C. Ducroux, M. Jandrot-Perrus, JB. Michel, M. Mazighi, D. Hendriks, JP. Desilles. Selective inhibition of CPU reduces microvascular thrombosis in an experimental rat stroke model. (Oral and poster presentation)
K. Claesen, JC. Mertens, C. Whyte, NJ. Mutch, D. Hendirks. Comparison of generation of CPU (TAFIa, CPB2) activity in two in vitro clot lysis systems. (Poster presentation)

*Awarded a GRC Poster Commendation Award

BSHT Annual Scientific Meeting | January 23-24, 2020 | Birmingham, United Kingdom

CS. Whyte, S. Westbury, R. Campbell Tait, NJ. Mutch, K. Kate Downes, JC. Mertens, K. Claesen, D. Hendriks, E. Leishman, A. Mumford. N.I.H.TR. Bio Resource. Coinheritance of TAFI variant ameliorates fibrinolytic alterations induced by thrombomodulin-associated coagulopathy. (Oral presentation)

27th BSTH Annual Meeting | November 28-29, 2020 | Mechelen, Belgium

JC. Mertens*, D. Leenaerts, W. Boisseau, L. Di Meglio, S. Loyau, AM. Lambeir, C. Ducroux, M. Jandrot-Perrus, JB. Michel, M. Mazighi, D. Hendriks, JP. Desilles. Evaluation of the time course of Carboxypeptidase U (CPU, CPB2, TAFIa) generation and influence of AZD9684, a selective CPU inhibitor, in experimental rat stroke models. (Oral presentation)
K. Claesen, JC. Mertens, S. De Belder, J. Maes, J. Bosmans, H. Stoffelen, I. De Meester, D. Hendriks. Evaluation of the influence of statin therapy on proCPU (TAFI, proCPB2) biology in patients eligible for statin therapy. (Oral presentation)

*Awarded with the Paul Capel Prize Basic research for the best oral presentation

BSPS 2019 Forum of Pharmaceutical Sciences | May 20, 2019 | Brussels, Belgium

JC. Mertens, K. Claesen, D. Leenaerts, Y. Sim, AM. Lambeir, D. Hendriks. The caboxypeptidase U system (CPU, TAFIa, CPB2) is inhibited by hemolysis in in vitro assays. (Oral presentation)
M. De bruyn, H. Ceuleers, J. De Man, N. Hanning, K. Augustyns, AM. Lambeir, B. De Winter, I. De Meester. Proteolytic activities in a rat TNBS-induced colitis model: influence of a single dose serine protease inhibitor treatment (UAMC0050). (Oral presentation)
E. De Hert, E. Janssens, I. De Meester. Prolyl carboxypeptidase as apelin-cleaving enzyme in human umbilical vein endothelial cells. (Oral presentation)
G. Vliegen, K. Kehoe, A. Bracke, E. De Hert, R. Verkerk, E. Fransen, B. ‘s Jongers, E. Peters, AM. Lambeir, S. Kumar-Singh, P. Pickkers, PG. Jorens, I. De Meester. Plasma proline‐specific peptidases in sepsis patients - Association with inflammatory, hemodynamic and metabolic parameters. (Oral presentation)

11^th General meeting of the International Proteolysis Society | September 29-October 4, 2019 | Prague, Czech Republic

M. De bruyn*, U-H. Stenman, H. Koistinen, I. De Meester. Peptide cleavage patterns as an approach to investigate serine protease activity. (Poster presentation)
G. Vliegen, K. Kehoe, A. Bracke, E. De Hert, R. Verkerk, E. Fransen, B. ’s Jongers, E. Peters, AM. Lambeir, S. Kumar-Singh, P. Pickkers, PG. Jorens, I. De Meester. Proline-specific enzymes as potential biomarkers in septic shock patients (sepsis-2). (Poster presentation)
A. De Decker**, G. Vliegen**, S. Benramdane, D. Van Rompaey, A. Peeraer, A. Bracke, L. Verckist, R. Geiss-Friedlander, K. Augustyns, I. De Meester, AM. Lambeir, P. Van Der Veken. Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP). (Poster presentation)

* IPS Traval Award

** First two authors contributed equally

Joint 12th EBSA & 10th ICBP-IUPAP Biophysics congress | July 20-24, 2019 | Madrid, Spain

P. Van Wielendaele, AM. Lambeir, Y. Sterckx, I. De Meester. Molecular interaction analysis of peptidases: from small molecule inhibitors to large macromolecules. (Poster presentation)

XXVII ISTH Congress and 65th Annual SSC meeting | July 6-10, 2019 | Melbourne, Australia

JC. Mertens, K. Claesen, D. Leenaerts, Y. Sim, AM. Lambeir, D. Hendriks. Inhibition of the procarboxypeptidase U (proCPU, TAFI, proCPB2) system due to hemolysis. (Poster presentation)

Hercules User Meeting, Phospho-peptide Kinome Profiling PamChip platform | 2019 | Antwerp, Belgium

G. Vliegen, C. Perez Novo, M. De bruyn, AM. Lambeir, W. Vanden Berghe, I. De Meester. The effect of the DPP8/9-inhibitor 1G244 on kinases in murine macrophages. (Oral presentation)

Departmental Research Day Pharmaceutical Sciences | 2019 | Antwerp, Belgium

G. Vliegen, K. Kehoe, A. Bracke, E. De Hert, R. Verkerk, E. Fransen, B. ‘s Jongers, E. Peters, AM. Lambeir, S. Kumar-Singh, P. Pickkers, PG. Jorens, I. De Meester. Plasma proline‐specific peptidases in sepsis patients - Association with inflammatory, hemodynamic and metabolic parameters. (Oral presentation)

ABPP 2019 Target Discovery and Visualisation using Chemical Probes | March 27-29, 2019 | Leuven, Belgium

A. De Decker*, G. Vliegen*, S. Benramdane, D. Van Rompaey, A. Peeraer, A. Bracke, L. Verckist, K. Jansen, K. Augustyns, H. De Winter, I. De Meester, AM. Lambeir, P. Van Der Veken. Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP).

* First two authors contributed equally