Molecular Imaging Center Antwerp

Publications - MICA

Selected Publications

The complete academic bibliography for each researcher can be found via 'Members'.

Below is a list of selected MICA (A1) publications:

2016

  • Vangestel C, Thomae D, Van Soom J, Ides J, Wyffels L, Pauwels P, Stroobants S,Van der Veken P, Magdolen V, Joossens J, Augustyns K, Staelens S. Preclinical evaluation of [(111) In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity. Contrast Media Mol Imaging. 2016 Aug 24. doi: 10.1002/cmmi.1706. [Epub ahead of print] PubMed PMID: 27558262.
  • Maggi A, Ruivo E, Fissers J, Vangestel C, Chatterjee S, Joossens J, Sobott F, Staelens S, Stroobants S, Van Der Veken P, Wyffels L, Augustyns K. Development of a novel antibody-tetrazine conjugate for bioorthogonal pretargeting. Org Biomol Chem. 2016 Aug 21;14(31):7544-51. doi: 10.1039/c6ob01411a. Epub 2016 Jul 19. PubMed PMID: 27431745.
  • Rapic S, Vangestel C, Verhaeghe J, Thomae D, Pauwels P, Van den Wyngaert T, Staelens S, Stroobants S. Evaluation of [(18)F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer. Mol Imaging Biol. 2016 Jun 20. [Epub ahead of print] PubMed PMID: 27324368.
  • Wyffels L, Verbrugghen T, Monnery BD, Glassner M, Stroobants S, Hoogenboom R, Staelens S. µPET imaging of the pharmacokinetic behavior of medium and high molar mass (89)Zr-labeled poly(2-ethyl-2-oxazoline) in comparison to poly(ethylene glycol). J Control Release. 2016 Aug 10;235:63-71. doi: 10.1016/j.jconrel.2016.05.048. Epub 2016 May 25. PubMed PMID: 27235979.
  • Capistrano R, Vangestel C, Wouters A, Dockx Y, Pauwels P, Stroobants S, Apers S, Lardon F, Pieters L, Staelens S. Efficacy Screening of Gloriosa Superba Extracts in a Murine Pancreatic Cancer Model Using (18)F-FDG PET/CT for Monitoring Treatment Response. Cancer Biother Radiopharm. 2016 Apr;31(3):99-109. doi: 10.1089/cbr.2015.1954. PubMed PMID: 27093343.
  • Waldron AM, Fissers J, Van Eetveldt A, Van Broeck B, Mercken M, Pemberton DJ, Van Der Veken P, Augustyns K, Joossens J, Stroobants S, Dedeurwaerdere S, Wyffels L, Staelens S. In Vivo Amyloid-β Imaging in the APPPS1-21 Transgenic Mouse Model with a (89)Zr-Labeled Monoclonal Antibody. Front Aging Neurosci. 2016 Mar 31;8:67. doi: 10.3389/fnagi.2016.00067. eCollection 2016. PubMed PMID: 27064204; PubMed Central PMCID: PMC4815004.
  • Deleye S, Waldron AM, Richardson JC, Schmidt M, Langlois X, Stroobants S, Staelens S. The Effects of Physiological and Methodological Determinants on 18F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model. Mol Imaging. 2016 Feb 11;15. pii: 1536012115624919. doi: 10.1177/1536012115624919. Print 2016. PubMed PMID: 27030402.
  • Parthoens J, Verhaeghe J, Servaes S, Miranda A, Stroobants S, Staelens S. Performance Characterization of an Actively Cooled Repetitive Transcranial Magnetic Stimulation Coil for the Rat. Neuromodulation. 2016 Jul;19(5):459-68. doi: 10.1111/ner.12387. Epub 2016 Feb 5. PubMed PMID: 26846605.
  • Fissers J, Waldron AM, De Vijlder T, Van Broeck B, Pemberton DJ, Mercken M, Van Der Veken P, Joossens J, Augustyns K, Dedeurwaerdere S, Stroobants S, Staelens S, Wyffels L. Synthesis and Evaluation of a Zr-89-Labeled Monoclonal Antibody for Immuno-PET Imaging of Amyloid-β Deposition in the Brain. Mol Imaging Biol. 2016 Aug;18(4):598-605. doi: 10.1007/s11307-016-0935-z. PubMed PMID: 26846128.
  • Elvas F, Vangestel C, Pak K, Vermeulen P, Gray B, Stroobants S, Staelens S, Wyffels L. Early Prediction of Tumor Response to Treatment: Preclinical Validation of 99mTc-Duramycin. J Nucl Med. 2016 May;57(5):805-11. doi: 10.2967/jnumed.115.168344. Epub 2016 Feb 2. PubMed PMID: 26837335.
  • Kosten L, Verhaeghe J, Verkerk R, Thomae D, De Picker L, Wyffels L, Van Eetveldt A, Dedeurwaerdere S, Stroobants S, Staelens S. Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction. Psychiatry Res. 2016 Feb 28;248:1-11. doi: 10.1016/j.pscychresns.2016.01.013. Epub 2016 Jan 12. PubMed PMID: 26803479.
  • De Bruycker S, Vangestel C, Van den Wyngaert T, Wyffels L, Wouters A, Pauwels P, Staelens S, Stroobants S. Baseline [(18)F]FMISO µPET as a Predictive Biomarker for Response to HIF-1α Inhibition Combined with 5-FU Chemotherapy in a Human Colorectal Cancer Xenograft Model. Mol Imaging Biol. 2016 Aug;18(4):606-16. doi: 10.1007/s11307-015-0926-5. PubMed PMID: 26728163.

2015

  • Waldron AM, Wintmolders C, Bottelbergs A, Kelley JB, Schmidt ME, Stroobants S, Langlois X, Staelens S. In vivo molecular neuroimaging of glucose utilization  and its association with fibrillar amyloid-β load in aged APPPS1-21 mice. Alzheimers Res Ther. 2015 Dec 15;7(1):76. doi: 10.1186/s13195-015-0158-6. PubMed  PMID: 26666747; PubMed Central PMCID: PMC4678474.
  • Shah D, Deleye S, Verhoye M, Staelens S, Van der Linden A. Resting-state functional MRI and [18F]-FDG PET demonstrate differences in neuronal activity between commonly used mouse strains. Neuroimage. 2016 Jan 15;125:571-7. doi: 10.1016/j.neuroimage.2015.10.073. Epub 2015 Oct 28. PubMed PMID: 26520769.
  • Waldron AM, Verhaeghe J, Wyffels L, Schmidt M, Langlois X, Van Der Linden A, Stroobants S, Staelens S. Erratum to: Preclinical Comparison of the Amyloid-β Radioligands [(11)C]Pittsburgh compound B and [(18)F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis. Mol Imaging Biol. 2015 Dec;17(6):893. doi: 10.1007/s11307-015-0905-x. PubMed PMID: 26514356.
  • Amhaoul H, Hamaide J, Bertoglio D, Reichel SN, Verhaeghe J, Geerts E, Van Dam D, De Deyn PP, Kumar-Singh S, Katsifis A, Van Der Linden A, Staelens S, Dedeurwaerdere S. Brain inflammation in a chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis. Neurobiol Dis. 2015 Oct;82:526-39. doi: 10.1016/j.nbd.2015.09.004. Epub 2015 Sep 24. PubMed PMID: 26388398.
  • Thomae D, Servaes S, Vazquez N, Wyffels L, Dedeurwaerdere S, Van der Veken P, Joossens J, Augustyns K, Stroobants S, Staelens S. Synthesis and preclinical evaluation of an 18F labeled PDE7 inhibitor for PET neuroimaging. Nucl Med Biol. 2015 Dec;42(12):975-81. doi: 10.1016/j.nucmedbio.2015.07.007. Epub 2015 Jul 29. PubMed PMID: 26330158.
  • Waldron AM, Wyffels L, Verhaeghe J, Bottelbergs A, Richardson J, Kelley J, Schmidt M, Stroobants S, Langlois X, Staelens S. Quantitative µPET Imaging of Cerebral Glucose Metabolism and Amyloidosis in the TASTPM Double Transgenic Mouse Model of Alzheimer's Disease. Curr Alzheimer Res. 2015;12(7):694-703. PubMed PMID: 26159204.
  • Parthoens J, Servaes S, Verhaeghe J, Stroobants S, Staelens S. Prelimbic Cortical Injections of a GABA Agonist and Antagonist: In Vivo Quantification of the Effect in the Rat Brain Using [(18)F] FDG MicroPET. Mol Imaging Biol. 2015 Dec;17(6):856-64. doi: 10.1007/s11307-015-0859-z. PubMed PMID: 25917751.
  • Elvas F, Vangestel C, Rapic S, Verhaeghe J, Gray B, Pak K, Stroobants S, Staelens S, Wyffels L. Characterization of [(99m)Tc]Duramycin as a SPECT Imaging Agent for Early Assessment of Tumor Apoptosis. Mol Imaging Biol. 2015 Dec;17(6):838-47. doi: 10.1007/s11307-015-0852-6. PubMed PMID: 25896815; PubMed
  • Waldron AM, Verhaeghe J, wyffels L, Schmidt M, Langlois X, Van Der Linden A, Stroobants S, Staelens S. Preclinical Comparison of the Amyloid-β Radioligands [(11)C]Pittsburgh compound B and [(18)F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis. Mol Imaging Biol. 2015 Oct;17(5):688-96. doi: 10.1007/s11307-015-0833-9. Erratum in: Mol Imaging Biol. 2015 Dec;17(6):893.

2014

  • Amhaoul H, Staelens S, Dedeurwaerdere S. Imaging brain inflammation in epilepsy. Neuroscience 2014; 279:238-252.
  • Deleye S, Heylen M, Deiteren A, De Man J, Stroobants S, De Winter B, Staelens S. Continuous flushing of the bladder in rodents reduces artifacts and improves quantification in molecular imaging. Mol Imaging. 2014;13:1-12. doi: 10.2310/7290.2014.00013. PubMed PMID: 24825484.
  • Deleye S, Verhaeghe J, wyffels L, Dedeurwaerdere S, Stroobants S, Staelens S. Towards a reproducible protocol for repetitive and semi-quantitative rat brain imaging with (18) F-FDG: exemplified in a memantine pharmacological challenge.
    Neuroimage 2014;96:276-287. doi: 10.1016/j.neuroimage.2014.04.004. Epub 2014 Apr 13. PubMed PMID: 24736171.
  • Ides J, Thomae D, Wyffels L, Vangestel C, Messagie J, Joossens J, Lardon F, Van der Veken P, Augustyns K, Stroobants S, Staelens S. Synthesis and in vivo preclinical evaluation of an (18)F labeled uPA inhibitor as a potential PET imaging agent. Nucl Med Biol. 2014 Jul;41(6):477-87. doi: 10.1016/j.nucmedbio.2014.03.019. Epub 2014 Mar 29. PubMed PMID: 24768145.
  • Parthoens J, Verhaeghe J, Stroobants S, Staelens S. Deep Brain Stimulation of the Prelimbic Medial Prefrontal Cortex: Quantification of the Effect on Glucose Metabolism in the Rat Brain Using [(18)F]FDG MicroPET.
    Mol Imaging Biol. 2014;16(6):838-845. PubMed PMID: 24943500.
  • Parthoens J, Wyckhuys T, Stroobants S, Staelens S. Small animal repetitive transcranial magnetic stimulation combined with [18F]-FDG microPET to quantify the neuromodulation effect in the rat brain. NeuroScience 2014;275:436-443.
  • Song JJ, Mertens G, Deleye S, Staelens S, Ceyssens S, Gilles A, de Bodt M, Vanneste S, De Ridder D, Kim E, Park SJ, Van de Heyning P. Neural Substrates of Conversion Deafness in a Cochlear Implant Patient: A Molecular Imaging Study Using H215O-PET. Otol Neurotol. 2014 Dec;35(10):1780-4. doi: 10.1097/MAO.0000000000000560. PubMed PMID: 25166017.
  • Wyckhuys T, Wyffels L, Langlois X, Schmidt M, Stroobants S, Staelens S. The [18F]FDG µPET readout of a brain activation model to evaluate the metabotropic glutamate receptor 2 positive allosteric modulator JNJ-42153605. J Pharmacol Exp Ther. 2014 Aug;350(2):375-86. doi: 10.1124/jpet.114.213959. Epub 2014 Jun 4 PubMed PMID: 24898267.
  • Wyffels L, Thomae D, Waldron AM, Fissers J, Dedeurwaerdere S, Van der Veken P, Joossens J, Stroobants S, Augustyns K, Staelens S. In vivo evaluation of (18)F-labeled TCO for pre-targeted PET imaging in the brain. Nucl Med Biol. 2014 Jul;41(6):513-23. doi: 10.1016/j.nucmedbio.2014.03.023. Epub 2014 Apr 2. PubMed PMID: 24768149.

2013

  • Deleye S, Van Holen R, Verhaeghe J, Vandenberghe S, Stroobants S, Staelens S. Performance evaluation of small-animal multipinhole µSPECT scanners for mouse imaging. Eur J Nucl Med Mol Imaging. 2013 May;40(5):744-58. doi: 10.1007/s00259-012-2326-2. Epub 2013 Jan 24. PubMed PMID: 23344137.
  • Heylen M, Deleye S, De Man JG, Ruyssers NE, Vermeulen W, Stroobants S, Pelckmans PA, Moreels TG, Staelens S, De Winter BY. Colonoscopy and µPET/CT are valid techniques to monitor inflammation in the adoptive transfer colitis model in mice. Inflamm Bowel Dis. 2013 Apr;19(5):967-76. doi: 10.1097/MIB.0b013e3182802c7c. PubMed PMID: 23407045.
  • Wyckhuys T, Verhaeghe J, Wyffels L, Langlois X, Schmidt M, Stroobants S, Staelens S. N-acetylcysteine- and MK-801-induced changes in glutamate levels do not affect in vivo binding of metabotropic glutamate 5 receptor radioligand 11C-ABP688 in rat brain.
    J Nucl Med. 2013 Nov;54(11):1954-61. doi: 10.2967/jnumed.113.121608. Epub 2013 Sep 19. PubMed PMID: 24050937.
  • Wyckhuys T, De Geeter N, Crevecoeur G, Stroobants S, Staelens S. Quantifying the effect of repetitive transcranial magnetic stimulation in the rat brain by µSPECT CBF scans.
    Brain Stimul. 2013 Jul;6(4):554-62. doi: 10.1016/j.brs.2012.10.004. Epub 2012 Oct 30. PubMed PMID: 23127432.