Gastrointestinal simulation model

Bioavailability and Metabolisation  
 
A GastroIntestinal Dialysis Model (GIDM-colon) was developed in the Laboratory of Nutrition and Functional Food Science. The physiological conditions of the stomach, small intestine and colon (with a culture of human colonic microflora) and the one way absorption by passive diffusion from lumen to mucosa  are simulated. This model is much faster, less expensive and easier to perform compared to in vivo tests, and helps in resolving the mechanism of metabolisation and the identification of the metabolites of active compounds, in combination with LC-MS and LC-NMR techniques.