Studying human metabolism using in silico and in vitro techniques

What?

  • Prediction and elucidation of Phase I & II metabolites & metabolic pathways
  • Characterization of alterations in cellular metabolites

How?

  • Elucidation of metabolism of chemicals using human liver microsomes (HLM)
  • Comparison of in vitro results with in vivo samples
  • Exposure of human cells to external stressors
  • Bioinformatic and statistical tools
  • Characterization of affected biochemical pathways​