The animal lab of UROLOGY (part of TNW) focuses on research related to sensory and motor function of the Lower Urinary Tract in small animals.
Special focuses are:
Bladder – Bowel interaction
Direct measurement of afferent activity
Intraurethral mechanical stimulation
Urethral – Bladder interaction
Autonomous bladder contractions
Major Pelvic Ganglion
New projects
Investigation of urethral sensation
Peripheral modulation of bladder sensation: motor-sensory system
Investigation of urethral sensation
The focus of this project is the expansion of the knowledge of the urethra, with special attention to the sensations and afferent information that have their origin in the urethra.
In order to function normally, the bladder and urethra need to work together as one unit. This coordinated activity is regulated by a complex neural control system, which incorporates different spinal and supraspinal reflex pathways, where the urethra plays an important role. It has been reported that afferent input from the urethra can modulate bladder function, both in animals and humans.
Though, little is known about the functional properties of urethral afferents. Such knowledge will allow greater insight into the role of urethral afferents in LUT function. In a first study, we identified and described the functional properties of urethral afferents responsive to urethral distention in the female rat [1].
To measure the potentials of urethral afferents, we have used the “single afferent activity (SAA) technique”. This technique has been abundantly used in our laboratory to measure bladder potentials [2-3]. In order to measure urethral afferents, the technique has been modified so that the afferent potentials of both pelvic and pudendal nerve can be measured. This technique will allow the study of urethral afferents under different interventions (distention, flow, drugs). Modulation of urethral afferent/sensory neurons may have a potential role in the treatment of certain pathologies of the LUT, such as stress urinary incontinence and overactive bladder.
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