Medical Biochemistry search menu search content Serine proteases Please navigate for more detailed information. Fibroblast activation protein (FAP) Prolylcarboxypeptidase (PRCP) Dipeptidyl peptidase 9 (DPP9) Profiling of serine protease activity Thymus specific serine protease (TSSP) Cookie prrefere…

Medical Biochemistry search menu search content Thymus specific serine protease (TSSP) The thymus specific serine protease or TSSP was identified in the late 90’s by two different laboratories1,2. It is the third member of the S28 group of serine proteases, the first member being Prolyl Carboxypep…

Medical Biochemistry search menu search content Profiling of serine protease activity Serine proteases are involved in many pathophysiological conditions throughout the human body (e.g. irritable bowel syndrome, acute lung injury, cancer, viral infections, …). As the lack of insight in the underly…

Info for companies search menu search content Life sciences License offers Serine protease inhibitors to treat visceral pain The University of Antwerp has developed an in vivo proof of concept with serine protease inhibitors in a validated gastrointestinal IBS model for visceral pain. Pharmaceutical…

Koen Augustyns full professor - dean Koen Augustyns Lectures at Scientific Symposia “Synthesis and properties of sugar modified oligonucleotides” Derde Forum der Farmaceutische Wetenschappen, Houffalize, Belgium (15-16/03/1991) “Dipeptidylpeptidase IV, a new target in the development of antidi…

Alba Ramos Llorca unpaid staff - senior researcher Research Alba Ramos Llorca Research team Medicinal Chemistry (UAMC) Design, Synthesis and Biochemical evaluation of novel serine protease activity-based probes. 01/10/2021 - 30/09/2022 Abstract Serine proteases are a subgroup of the protease family …

Jurgen Joossens domain coord.- head of service Publications Jurgen Joossens The effect of serine protease inhibitors on visceral pain in different rodent models with an intestinal insult Source Frontiers in pharmacology - ISSN 1663-9812-13 (2022) p. 1-17 Author(s) Hannah Ceuleers, Nikita Hanning, Mi…

Simon Scharpe emeritus occasional assignment Research Simon Scharpe Research team Medical Biochemistry Comparative biochemical and functional study of the different dipeptidyl peptidases. 01/01/2009 - 31/12/2012 Abstract this research project studies proline selective peptidases. It has the followin…

Alba Ramos Llorca unpaid staff - senior researcher Publications Alba Ramos Llorca Design, synthesis and evaluation of novel activity-based probes and inhibitors for trypsin-like serine proteases : focus on Dry eye disease (DED) and Irritable bowel syndrome (IBS) Source Antwerp, University of Antwerp…

Infla-Med search menu search content Opportunities New technology offer: highly selective, orally bioavailable FAP inhibitors Please see the following link/ https://medialibrary.uantwerpen.be/oldcontent/container39124/files/TTO-15-E-1706-FAP_Inhibitors.pdf Technology offer: New lead compounds for dr…

Integrated Training in Dry Eye Disease Drug Development search menu search content ESR1 Alba Ramos Llorca Research project: Design, Synthesis and Biochemical evaluation of novel serine protease inhibitors. Host organisation: University of Antwerp (UA), Belgium Supervisor: Prof. Dr. Koen AUGUSTYNS Br…

Integrated Training in Dry Eye Disease Drug Development search menu search content #ProjectOverview ESR1: Design, Synthesis and Biochemical evaluation of novel serine protease inhibitors. University of Antwerp ESR2: Design, Synthesis and Biochemical evaluation of novel RIPK1 inhibitors. University o…

Integrated Training in Dry Eye Disease Drug Development search menu search content Research Projects ESR1: Design, Synthesis and Biochemical evaluation of novel serine protease inhibitors. University of Antwerp ESR2: Design, Synthesis and Biochemical evaluation of novel RIPK1 inhibitors. University …

Koen Augustyns full professor - dean Koen Augustyns PhD Students 26/09/2000 Gabrielle Thonus: Design, synthesis and biological evaluation of opioid-related prolyl peptides and pseudopeptides 10/11/2000 XueMei Zhang: Design, synthesis and evaluation of dipeptidyl peptidase IV (DPP IV) inhibitors 25/0…

Pharmaceutical, Biomedical and Veterinary Sciences Defences 2019 Department of Pharmaceutical Sciences Defences 2019 Department of Pharmaceutical Sciences What contribute to human exposure to organophosphate esters flame retardants? An experimental approach - Fuchao Xu (16/12/2019) Fuchao Xu 16 Dece…

Maya Berg research manager Publications Maya Berg Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases Source Frontiers in Chemistry - ISSN 2296-2646-10 (2023) p. 1-17 Author(s) Alba Ramos Llorca, Lisse Decraecker, Valerie Cacheux, Ir…

Integrated Training in Dry Eye Disease Drug Development search menu search content Doctoral Theses January 15th, 2024 Development of New Carriers to Improve the Bioavailability of Natural Compounds for the Treatment of Ocular Surface Disorders Author: Luna Krstić, University of Valladolid Superviso…

Veerle Matheeussen associate professor - unpaid guest prof. Research Veerle Matheeussen Research team Medical Biochemistry Expertise Evaluation of (molecular) diagnostic assays for detection of respiratory viruses and bacteria Surveillance of vancomycin and linezolid resistance in Enterococci Detect…

Medical Biochemistry search menu search content Dipeptidyl peptidase 9 (DPP9) DPP9 in a nutshell Dipeptidyl peptidase 9 (DPP9), an intracellular serine protease, has recently been identified as a key player in pro-inflammatory cell death and regulation of the innate immune response. Similar to its c…

Integrated Training in Dry Eye Disease Drug Development search menu search content SYMPOSIUM 'DRY EYE DISEASE' LIVE-STREAMING EVENT | 2 December 2021 DOWNLOAD PROGRAMME Opening & Welcome Note | Christophe Baudouin, MD, PhD. President of the European Dry Eye Society - EuDES. Professor of Ophthalmolog…

Info for companies search menu search content Life sciences License offers New lead compounds for dry eye disease and validated dry eye rat model The University of Antwerp has developed a new lead compound and a validated rat model for dry eye disease (DED). Pharmaceutical companies looking for a pr…

Margarida Florindo Espadinha postdoctoral scholarship hold. Research Margarida Florindo Espadinha Research team Medicinal Chemistry (UAMC) DPP9 degradation-induced pyroptosis for treatment of acute myeloid leukemia (DPP9-TACDrug). 01/04/2023 - 31/03/2025 Abstract Dipeptidyl-peptidase 9 (DPP9) is a p…

Integrated Training in Dry Eye Disease Drug Development search menu search content Technology offers New lead compounds for dry eye disease and validated dry eye disease rat model Please also see the publication A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular…

Medical Biochemistry search menu search content Research topics The basic research interest is always to find novel targets and unravel the structure-function relationship of target proteins within a given pathophysiological context. The current research topics are: Serine proteases Carboxypeptidase…

Medical Biochemistry search menu search content Poster and oral presentations 21st Forum of Pharmaceutical Sciences, organised by the Belgian Society of Pharmaceutical Sciences | April 27-28, 2023 | Blankenberge, Belgium M. Florindo Espadinha, J. De Loose, S. Benramdane, S. Corthaut, P. Van Wielenda…