Abstract
Indonesia, home to the world's second-largest biodiversity, possesses around 40,000 endemic plant species, including 6,000 medicinal plants. Despite a long tradition of herbal medicine (Jamu), many medicinal plants remain underexplored, particularly for their anti-inflammatory properties. Chronic diseases such as arthritis, cancer, and diabetes are associated with inflammation, and a need for alternative treatments is still present. Previous research has identified some Indonesian plants with anti-inflammatory potential, but many remain unstudied.
This project aims to investigate the anti-inflammatory properties of medicinal plants traditionally used in Jamu by evaluating their in vitro anti-inflammatory activity and gastrointestinal metabolism. The study will identify bioactive phytochemicals responsible for these effects and explore their formulation into herbal supplements or functional food products. The research will be structured into five key phases: (1) selection of 10-20 medicinal plants based on literature review, (2) assessment of their in vitro anti-inflammatory activity via inhibition of COX-1/COX-2 enzymes, NF-kB activation, TNF-α release, and NO formation, (3) phytochemical profiling and isolation of active constituents using HPLC-DAD, LC-MS and NMR spectroscopy, (4) development of analytical methods for quantification of active constituents and formulation of supplements, and (5) a comprehensive conclusion and future perspectives.
Thus, this research will employ advanced chromatographic and spectroscopic techniques alongside in vitro assays. The findings will contribute to the knowledge of phytopharmacology, while supporting the preservation and commercialization of Jamu, which is part of Indonesian cultural heritage. Furthermore, this research will provide a scientific basis for developing evidence-based herbal medicines or food supplements, enhancing public health, and expanding the Indonesian herbal product industry.
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