Research team
Price 'Gelijke Kansenbeleid' (equal opportunities policy) University of Antwerp.
Experimental and cell biological assessment of the effects of lanthanum and strontium on osteoblast function and process of bone mineralization
Abstract
Following previous findings in the Laboratory of Nephrology-Hypertension demonstrating both strontium and lanthanum to induce bone lesions in an experimental rat model with chronic renal failure, which histologically are expressed as osteomalacia, it will in the present research project be investigated wether the mineralization defect resulting from exposure to these elements, develops via an identical pathway. Therefore it will be assessed whether the disturbed mineralization is due to a pure physicochemical, extracellular process or on the other hand occurs via a direct effect on the osteoblast. Also will the interference of both elements with the secretion/synthesis of a series of relevant bone matrix proteins be investigated. To find an answer to these questions in vitro (primary osteoblast cultures) as well as in vivo (rat model with chronic renal failure) set-ups will be applied.Researcher(s)
- Promoter: D'Haese Patrick
- Co-promoter: De Broe Marc
- Fellow: Bervoets An
Research team(s)
Project type(s)
- Research Project
Experimental and cell biological assessment of the effects of lanthanum and strontium on osteoblast function and process of bone mineralization
Abstract
Following previous findings in the Laboratory of Nephrology-Hypertension demonstrating both strontium and lanthanum to induce bone lesions in an experimental rat model with chronic renal failure, which histologically are expressed as osteomalacia, it will in the present research project be investigated wether the mineralization defect resulting from exposure to these elements, develops via an identical pathway. Therefore it will be assessed whether the disturbed mineralization is due to a pure physicochemical, extracellular process or on the other hand occurs via a direct effect on the osteoblast. Also will the interference of both elements with the secretion/synthesis of a series of relevant bone matrix proteins be investigated. To find an answer to these questions in vitro (primary osteoblast cultures) as well as in vivo (rat model with chronic renal failure) set-ups will be applied.Researcher(s)
- Promoter: De Broe Marc
- Fellow: Bervoets An
Research team(s)
Project type(s)
- Research Project