Research Angelique Van Ombergen

Abstract

The world population has been aging dramatically, with 12% aged 60 years or older, and a rising number developing dementia. Yet, until now no cure or therapy to slow down the disease has been identified. Recent studies have established that hearing loss increases the risk for developing dementia. Because hearing loss can be treated with a hearing aid or cochlear implantation, this could potentially delay the onset of dementia. Many studies have reported improvement in cognition after hearing rehabilitation, but this might have been caused by just hearing the mostly verbal tests better. Many studies have demonstrated that balance organ function, located in the inner ear, also has an effect on cognition. However, while hearing loss and balance organ function loss often occur simultaneously, it has not been systematically evaluated in older adults. Our aim is to study the effect of hearing loss and balance organ function loss on learning and memory (i.e. cognition) in older subjects (55 years or older) and patients with mild cognitive impairment and Alzheimer's disease. We will do so by systematically evaluating hearing and vestibular function in these subjects, by using a cognitive assessment tool that is adapted to a potentially hearing impaired population, by using objective measurements of electrical activity in the auditory cortex evoked by sound and by analyzing MRI volume changes in relevant areas of the brain to detect who is at risk for developing cognitive impairment.

Researcher(s)

• Promoter: Van Rompaey Vincent
• Co-promoter: Cras Patrick
• Co-promoter: Mertens Griet
• Co-promoter: Van Ombergen Angelique

Research team(s)

• Translational Neurosciences (TNW)

Project type(s)

• Research Project

Abstract

The overall objective of our research is to determine whether biomarkers of neuroplasticity in vestibular signal processing can be found using the model of microgravity. More specific the following objectives are set: a) to obtain knowledge on how astronauts adapt to microgravity at the level of the brain b) to use the model of microgravity to gain insight in which specific regions of interest are involved in space motion sickness, spatial disorientation, vertigo, and convergence of otolith and semicircular canal signals. c) to understand mechanisms of neuroplasticity in patients with vestibular dysfunction

Researcher(s)

• Promoter: Wuyts Floris
• Co-promoter: Parizel Paul
• Co-promoter: Van de Heyning Paul
• Fellow: Van Ombergen Angelique

Research team(s)

• Lab for Equilibrium Investigations and Aerospace (LEIA)

Project type(s)

• Research Project

Abstract

The overall objective of our research is to determine whether biomarkers of neuroplasticity in vestibular signal processing can be found using the model of microgravity. More specific the following objectives are set: a) to obtain knowledge on how astronauts adapt to microgravity at the level of the brain b) to use the model of microgravity to gain insight in which specific regions of interest are involved in space motion sickness, spatial disorientation, vertigo, and convergence of otolith and semicircular canal signals. c) to understand mechanisms of neuroplasticity in patients with vestibular dysfunction

Researcher(s)

• Promoter: Wuyts Floris
• Co-promoter: Van de Heyning Paul
• Fellow: Van Ombergen Angelique

Research team(s)

• Lab for Equilibrium Investigations and Aerospace (LEIA)

Project type(s)

• Research Project