Research team

Expertise

Bioassay-guided isolation of active principles of medicinal plants Structure elucidation of natural products Drug analysis

Development of new antiparasitic lead compounds against malaria, trypanosomiasis en leishmaniasis : a multidisciplinary approach. 01/01/2004 - 31/12/2007

Abstract

Parasitic infections such as malaria, trypanosomiasis and leishmaniasis still make a lot of victims every year, especially in developing countries. The aim of this project is to investigate new lead compounds for drugs against these diseases using a multidisciplinary approach: characterisation of new leads from medicinal plants; further investigations of indoloquinoline derivatives, an existing lead; and design of inhibitors of trypanothionsynthetase and prolyloligopeptidase.

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    • Research Project

    Structure-activity relationship investigation in correlation with bioavailability of proanthocyanidins as nutritional antioxidants. 01/01/2003 - 31/12/2006

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      • Research Project

      Investigation of antioxidant and antiviral natural products from medicinal plants for developing a complementary therapeutical strategy against HSV- and HIV-infections. 01/10/2002 - 30/09/2005

      Abstract

      In this research antiviral and antioxidant compounds will be isolated from medicinal plants in order to develop a complementary therapeutical strategy against HSV- and HIV-infections.

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        • Research Project

        Characterisation of the antimalarial constituents of 4 medicinal plants from Congo. 01/01/2002 - 31/12/2003

        Abstract

        This project deals with the characterisation of the antimalarial (antiplasmodial) constituents of 4 plants used in traditional medicine in Congo, the activity of which has been confirmed in preliminary in vivo experiments in mice, i.e. Phyllanthus niruri, Cassia occidentalis, Euphorbia hirta and Morinda morindoides. The aim of the project is to find new leads for antimalarial drugs, and to provide a scientific basis for the traditional use of local preparations, including the possibility of standardisation.

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          • Research Project

          Structure elucidation of biologically active natural products as prototypes for new drugs. 01/10/1999 - 30/09/2003

          Abstract

          Biologically active natural products from higher plants are isolated and identified, to serve as prototypes for potential new drugs.

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            • Research Project

            01/10/1999 - 30/09/2000

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              • Research Project

              28/02/1999 - 30/11/1999

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                • Research Project

                Structure-activity relationship of triterpenes as selective endothelin receptor antagonists. 01/01/1999 - 31/12/2002

                Abstract

                The goal is to investigate a large numher of tetracyclic and pentacyclic triterpene aglycones for their potential antihypertensive action. In vitro radio ligand binding to receptors with known antihypertensive action such as ETA-receptors for endo-thelin-1 and ATl-receptors for angiotensin II will be used to characterize the active triterpenes. More specifically a structure-activity relationship study will be carried out on myriceric acid A. For that reason a practica! partial synthesis of 27-0-acyl-myriceron derivatives will be adapted.

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                  • Research Project

                  01/04/1998 - 31/03/2000

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                    • Research Project

                    Mass spectrometric structure characterisation of biomolecules and functional dyes: study of ionisation and fragmentation mechanisms, development of methods and analytical applications. 01/01/1998 - 31/12/2001

                    Abstract

                    The proposed research programme deals with mass spectrometric studies on the structural characterisation of biomolecules which will remain of fundamental biological interest and of functional dyes which are important for their material properties. The molecules which will be studied include lipide, plant glycoconjugates, peptides, proteins and aromatic oligomers and polymers. The objectives are to examine in detail and systematically the unimolecular chemistry of some of these compounds in the gas phase.

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                      • Research Project

                      Isolation, structure elucidation and standardization of the active components from extracts prepared from the fruits of Sabal serrulata and the herb of Echinacea purpurea. 01/10/1997 - 31/10/1997

                      Abstract

                      The aim of the project is to identify the active components of Sabal serrulata fruits, which is used often in combination with Echinacea purpurea for the treatment of benign prostatic hyperplasia (BHP) and to determine their mechanics of action.

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                        • Research Project

                        Development and optimalisation of an in vivo antioxidative testsystem. 01/01/1997 - 31/12/2000

                        Abstract

                        Development and optimalisation of an in vivo antioxidative testsystem.(lipid peroxidation) for the antioxidative evaluation of pure compounds and for the bioguided isolation of antioxidative compounds from plant material.

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                          • Research Project

                          Structure elucidation of biologically active natural products as prototypes for new drugs. 01/10/1996 - 30/09/1999

                          Abstract

                          Biologically active natural products from higher plants are isolated and identified, to serve as prototypes for potential new drugs.

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                            • Research Project

                            01/10/1996 - 30/09/1997

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                              • Research Project

                              Structure elucidation of natural prototypes and synthetic analogues as potential new drugs by nuclear magnetic resonance (NMR) spectroscopy. 01/01/1996 - 31/12/2001

                              Abstract

                              Biologically active natural compounds from higher plants are used as prototype for the synthesis of analogues, to improve the activity, to study structure-activity relationship, in order to obtain potential new drugs. Structure of isolated and synthetic compounds will be elucidated using NMR spectroscopy.

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                                • Research Project

                                Isolation, structure elucidation and standardization of the active components from extracts prepared from the fruits of Sabal serrulata and the herb of Echinacea purpurea. 01/10/1995 - 30/09/1997

                                Abstract

                                The aim of the project is to identify the active components of Sabal serrulata fruits, which is used often in combination with Echinacea purpurea for the treatment of benign prostatic hyperplasia (BHP) and to determine their mechanics of action.

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                                  • Research Project

                                  Search for natural products with immunostimulating and/or anti-HIV activity. 01/10/1994 - 30/06/1995

                                  Abstract

                                  In view of the need for new drugs against AIDS, a viral disease suppressing the immune system, the aim of this project is to identify new natural products with potential immunostimulating and/or anti-HIV activity.

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                                    • Research Project

                                    Determining European standards for the safe and effective use of phytomedicines. 01/01/1994 - 31/12/1996

                                    Abstract

                                    The objective is to publish agreed standards as Sumaries of Product Characteristics or monograph proposals for 200 phytomedicines in the member states of the European Community.

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                                      • Research Project

                                      Structure activity relationship studies (SAR) and determination of the mechanism of action of antivirally active plant compound. 01/01/1994 - 31/12/1994

                                      Abstract

                                      New antiicornavirus flavonoids and antiherpes procyanidines will be synthetised and their antiviral activity will be determined. The investigation of the mechanism of action of these compounds will be continued.

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                                        • Research Project

                                        Search for plant components with immunostimulating and/or anti-HIV properties 01/10/1993 - 30/09/1995

                                        Abstract

                                        The active components of plant extracts with immunostimulating and/or anti-HIV properties will be isolated and identified using chromatographic and spectroscopic techniques. The biochemical mechanism of action will be investigated and determined.

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                                          • Research Project

                                          Isolation and structure elucidation of biologically active natural compounds as prototypes of potential new drugs. 01/10/1993 - 30/09/1994

                                          Abstract

                                          This research project deals with the biologically guided isolation of natural compounds with chemotherapeutic, antimutagenic, antitumoral, immunomodulating and enzym-inhibiting properties, their structure elucidation by means of spectroscopic techniques and their development as prototypes of potential new drugs.

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                                            • Research Project

                                            Comparison of high-performance liquid chromatography, thin-layers densitometry, supercritical fluid chromatography and capillary electrophores in plant drug analysis. 01/10/1993 - 31/03/1994

                                            Abstract

                                            The aim of the project is to compare the possibilities of some recently developed analytical technique to separate, identify and assay plant phenolics and flavanoids in complex matrices such as galenical preparations.

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                                              • Research Project

                                              In vivo antioxidant activity of flavonoïds. 01/07/1993 - 30/06/1994

                                              Abstract

                                              The aim of this research project is to investigate the antioxidatieve effect of flavonoids in laboratory animals, by adding these compounds to the diet and determing their influence on the blood plasma malondialdehyde level.

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                                                • Research Project

                                                Development of plant drugs. 01/04/1993 - 31/12/1996

                                                Abstract

                                                The aim of the project is to formulate plant drugs and to standardize their active constituents by modern analytical techniques.

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                                                  • Research Project

                                                  Isolation and structure elucidation of biologically active natural compounds as propotypes of potential new drugs. 01/01/1993 - 31/12/1993

                                                  Abstract

                                                  This project involves the biologically guided isolation of the active components of plants used in traditional medicine. When a pure, active compound has been obtained, its structure is elucidated by a combined use of spectroscopic techniques. The most interesting products may be used as prototypes for synthesis or semisynthesis of derivates, to improve the activity in order to obtain potential new drugs.

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                                                    Synthesis and antiviral properties of aza-analogues of 3-mehtoxyflavones 01/10/1992 - 30/09/1993

                                                    Abstract

                                                    Improvement of the antiviral spectrum and activity of 3-methoxylflavones by introducing nitrogen in the A-ring of the flavonoid skeleton.

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                                                      • Research Project

                                                      Comparison of high-performance liquid chromatography, thin-layers densitometry, supercritical fluid chromatography and capillary electrophores in plant drug analysis. 01/10/1992 - 30/09/1993

                                                      Abstract

                                                      The aim of the project is to compare the possibilities of some recently developed analytical technique to separate, identify and assay plant phenolics and flavanoids in complex matrices such as galenical preparations.

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                                                        • Research Project

                                                        Study of antimutagenic activity of flavonoids. 01/09/1992 - 30/06/1993

                                                        Abstract

                                                        Flavanoids are natural products occuring in plants and foodstuffs. They have mutagenic and antimutagenic properties, depending on their structure. The aim of this work is to investigate the structure-activity relationship and to characterise the most active antimutagenic flavonoids.

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                                                          Search for new antivirally active natural compounds and optimalisation of their activity by structure-activity relationship studies. 01/01/1992 - 31/12/1997

                                                          Abstract

                                                          Antivirally active compounds isolated from medicinal plants will be used as lead products for the synthesis of analogues in order to optimize their antiviral and pharmacokinetic properties.

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                                                          • Promoter: Vlietinck Arnold
                                                          • Co-promoter: Haemers Achiel
                                                          • Co-promoter: Vanden Berghe Dirk

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                                                            • Research Project

                                                            01/01/1992 - 31/12/1992

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                                                              Search for plant components with immunostimulating and/or anti-HIV properties 01/10/1991 - 30/09/1993

                                                              Abstract

                                                              The active components of plant extracts with immunostimulating and/or anti-HIV properties will be isolated and identified using chromatographic and spectroscopic techniques. The biochemical mechanism of action will be investigated and determined.

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                                                                • Research Project

                                                                Chromatographic and structural investigations of ì chemotherapeutically active plant phenolicsì 01/10/1991 - 30/09/1993

                                                                Abstract

                                                                The structure of chemotherapeutically active plant condensed tannins viz. dimeric and trimeric procyanidines of the A, B and C-series will be determined by means of two dimensional nuclear magnetic resonance (2-D-NMR) spectrometry

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                                                                  • Research Project

                                                                  01/01/1991 - 31/12/1991

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                                                                    01/01/1991 - 31/12/1991

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                                                                      01/10/1990 - 30/09/1992

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                                                                        Chromatographic and structural investigations of ì chemotherapeutically active plant phenolicsì 01/10/1989 - 30/09/1991

                                                                        Abstract

                                                                        The structure of chemotherapeutically active plant condensed tannins viz. dimeric and trimeric procyanidines of the A, B and C-series will be determined by means of two dimensional nuclear magnetic resonance (2-D-NMR) spectrometry

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                                                                          • Research Project

                                                                          01/01/1989 - 31/12/1993

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                                                                            • Research Project

                                                                            01/01/1989 - 31/12/1989

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                                                                              • Research Project