Psychotic depression in older adults (60+) as prodrome/risk factor for cognitive deterioration/dementia.
Abstract
Psychotic depression in older adults is a severe and debilitating disorder. Up to half of older adults presenting with depressive symptoms also experience psychotic symptoms. Mostly, psychotic symptoms include delusions on financial, somatic or nihilistic themes. Particularly in late life, the depressive symptoms in psychotic depression are more severe than in non-psychotic depression, which is also the case when compared to psychotic depression in younger adults. Moreover, (depressed) older adults exhibit problems in different cognitive domains such as executive functioning, attention and memory. In younger depressed patients, cognitive problems ameliorate when they reach remission, but in older patients remission of depression often doesn't mean resolution of their cognitive problems. Although earlier research, inconsistently, showed that latelife depression may be a prodrome or risk factor for cognitive decline and dementia, little is known about the relation between late-life psychotic depression and incident cognitive decline. In this study, patients with a psychotic depressive episode at baseline are being monitored regarding their cognitive functioning at regular intervals during a period of 18 months, and compared to a control group of older adults with non-psychotic major depression. Both global and specific cognitive functioning (executive function, (working) memory, and attention) is being assessed.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Vermeulen Tom
Research team(s)
Project type(s)
- Research Project
Research in the field of psychiatry and that of medical psychology.
Abstract
I would like to undertake research work in the period in two areas: the first in the field of psychiatry, the second that of medical psychology. It covers the following research projects: 1 ) Antwerp ROM Data on patients suffering from treatment-resistant depression ( TRD) . The aim of the study is to outline a research strategy for the next few years with the analysis of the first 200 patients of this unique database. Expected output A1 publications on data analyzes ; final research plan purposely multiple PhD projects within the line " depression " of the Department of CAPRI (Collaborative Antwerp Psychiatric Research Institute: www.uantwerpen.be/nl/onderzoeksgroep/capri ) 2 ) Medical psychological literature about the conceptions of body, body image and body image in the major Western philosophical trends . Expected output: course text book plusResearcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
Subtypes in the Borderline Personality Disorder, their validation and treatment trajectory.
Abstract
Despite the possibility to diagnose the Borderline Personality Disorder (BPD), defined as a persistent pattern of unstable interpersonal relationships, self-image and emotions, and strong impulsiveness, still considerable heterogeneity is observed in the BPD population, which makes diagnosis and treatment of these patients difficult. The classification of BPD into subtypes on the basis of temperament and emotion regulation has theoretical and clinical implications. For example, based on the temperament profiles of BPD patients, one can develop person-specific treatment. Therefore, the first aim of this project is to investigate whether we can define subtypes of BPD patients based on temperamental features and to investigate whether these subtypes differ with respect to psychopathology and coping (e.g., psychiatric symptoms, emotion regulation). The second aim of the present project is to investigate whether the different BPD subtypes will react differently on the treatment they will undergo. During the last two years, we have collected data of 150 patients with BPD in two psychiatric units specialized in the treatment of BPD based on the Dialectic Behavioral Therapy. The participants were assessed by both, direct (interview and questionnaires) and indirect measures (performance-based tasks) of temperamental features, coping styles (e.g. dissociation) and psychopathology (e.g., non-suicidal self-injury, depression, alexithymia) and are followed during treatment.Researcher(s)
- Promoter: Sabbe Bernard
- Co-promoter: Claes Laurence
- Fellow: Sleuwaegen Ellen
Research team(s)
Project type(s)
- Research Project
Development of Translational Medicine Models for the Evaluation of Antidepressant Therapies.
Abstract
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
Stepped Care Translational Research Platform for Treatment-Resistant Depression.
Abstract
This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Co-promoter: Van den Bulcke Tim
Research team(s)
Project type(s)
- Research Project
Psychological and behavioral trait-frailties in the etiopathogenesis of severe major depressive disorder.
Abstract
The research project aims at investigating underlying psychological and behavioral mechanisms of severe major depressive disorder. Therefore two lines of research were set up. In the first part, the personality structure of patients was assessed extensively by means of rating scales and questionnaires. In the second part, neuropsychological assessment techniques were applied to investigate psychomotor functioning in geriatric patients with MDD.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Beheydt Lieve
Research team(s)
Project type(s)
- Research Project
Electroconvulsive therapy (ECT) in the Major Depressive Disorder : further research into ECT impact on psychomotor and cognitive symptoms and to optimize maintenance treatment schedules.
Abstract
This project represents a formal research agreement between UA and on the other hand Emmaus. UA provides Emmaus research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Van Diermen Linda
Research team(s)
Project type(s)
- Research Project
The cognitive factors of functional outcome in bipolar and psychotic disorders.
Abstract
This project represents a formal research agreement between UA and on the other hand Emmaus. UA provides Emmaus research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Van Camp Lynn
Research team(s)
Project type(s)
- Research Project
Multimodal investigation of a neuroinflammatory model in bipolar disorder.
Abstract
This project represents a formal research agreement between UA and on the other hand Emmaus. UA provides Emmaus research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: van den Ameele Seline
Research team(s)
Project type(s)
- Research Project
Research in the field of adult psychiatry.
Abstract
This project represents a formal research agreement between UA and on the other hand PZ Duffel. UA provides PZ Duffel research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
Set up protocols in demand clarification by the youth crisis hotlines.
Abstract
This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
Multimodal investigation of a neuroinflammatory model in schizophrenia.
Abstract
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: De Picker Livia
Research team(s)
Project type(s)
- Research Project
Social cognition from pole to pole: a study of social cognition in the affective phases of bipolar disorder.
Abstract
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Temmerman Anke
Research team(s)
Project type(s)
- Research Project
454 sequencing-based identification of causal variants for schizophrenia and bipolar disorder in multi-generational families.
Abstract
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Van Den Bossche Maarten
Research team(s)
Project type(s)
- Research Project
Intensive treatment for patients with dual diagnosis.
Abstract
This project represents a formal research agreement between UA and on the other hand PZ St.-Norbertus. UA provides PZ St.-Norbertus research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
To do or not to do? Effort-based decision making in schizophrenia.
Abstract
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Docx Lise
Research team(s)
Project type(s)
- Research Project
Social behavior in schizophrenia: a neurocognitive approach.
Abstract
Since the recognition of 'Social Cognition' as an important impairment in schizophrenic patients more research has been performed within this domain. Most experiments in this domain worked with passive tasks that hardly approached realistic social situations. Against this are a lot more 'active' studies of social cognition in healthy volunteers. Now it appears that brain areas of healthy people which are involved in social cognition have much overlap with the disrupted brain regions of schizophrenic patients in other tasks than social cognition. Therefore this research want to break with the shortcomings of current research within the domain of social cognition (1) by using paradigms that focus on actual behavior in social contexts, (2) by creating real social interactive situations in which tasks are shared among participants, (3) and by means of EEG and fMRI methodology.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: de la Asuncion Elvira Javier
Research team(s)
Project type(s)
- Research Project
Neuropsychology and electrophysiology of cognitive impairment in schizophrenia.
Abstract
This project represents a formal research agreement between UA and on the other hand a privé institution. UA provides the privé institution research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
454 sequencing-based identification of causal variants for schizophrenia and bipolar disorder in multi-generational families.
Abstract
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Van Den Bossche Maarten
Research team(s)
Project type(s)
- Research Project
Poly drug using and mental health among drug users who have a demand for treatment (POLYMEH).
Abstract
This project represents a formal research agreement between UA and on the other hand the Federal Public Service. UA provides the Federal Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Co-promoter: Dom Geert
Research team(s)
Project type(s)
- Research Project
Diagnosis of the psychomotor syndrome in schizophrenia.
Abstract
This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
Scientific chair "Advanced research and development in addiction medicine & psychiatry".
Abstract
This project represents a formal research agreement between UA and on the other hand a private institution. UA provides the private institution research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Co-promoter: Van Damme Pierre
Research team(s)
Project type(s)
- Research Project
Social-functional relevance and underlying neural mechanisms of action disturbances in depression.
Abstract
This is a fundamental research project financed by the Research Foundation - Flanders (FWO). The project was subsidized after selection by the FWO-expert panel.Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
Study of impuls controle with alcohol addiction.
Abstract
Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Bolangier Elke
Research team(s)
Project type(s)
- Research Project
psychomotor symptoms in depression.
Abstract
The first part of this project aims to investigate the relationship between functional outcome and psychomotor retardation in a large group of depressed patients. In addition, the relationship will be explored between fine and gross motor activity, two important domains in the cluster of psychomotor symptoms. The second part of this project will concentrate on the brain activity accompanying the disturbances of action. Applying EEG and functional imaging techniques, activity in the (merely prefrontal) brain structures will be investigated in the different subtypes of depression (severe depressed with and without retardation and dysthymia). It is expected that the pattern of brain activity in depressed patients without disturbances of action substantially will differ from the pattern of those depressed patients with manifest psychomotor retardation.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Destoop Marianne
Research team(s)
Project type(s)
- Research Project
Identification of susceptibility genes for schizophrenia.
Abstract
The aim of this project is to perform molecular genetics research to improve our knowledge about the etiology of schizophrenia (SZ) in general and of cognitive functioning in these patient in particular. The main goal is to establish a biobank with biological material (DNA, cellines, plasma) combined with detailed fenotypic data of unrelated SZ patients. Also we will collect large multigenerational families for linkage studies. DNA from this biobank will be used for molecular genetics/genomics analyses.Researcher(s)
- Promoter: Del-Favero Jurgen
- Co-promoter: Sabbe Bernard
- Fellow: Van Den Bossche Maarten
Research team(s)
Project type(s)
- Research Project
Effects of long-term treatment with Modalfinil on the relapse and impulse controle with alcohol-addicted patients.
Abstract
This project represents a formal research agreement between UA and on the other hand PC B. Alexianen. UA provides PC B. Alexianen research results mentioned in the title of the project under the conditions as stipulated in this contract.Researcher(s)
- Promoter: Sabbe Bernard
- Fellow: Joos Leen
Research team(s)
Project type(s)
- Research Project
Additional research of the effectiveness and efficiency of treatment programmes, specifically for patients with a double diagnosis.
Knowledge and application of evidence-based directives in the care and treatment of drug addicts.
Depression and action monitoring.
Abstract
Researcher(s)
- Promoter: Sabbe Bernard
- Co-promoter: Hulstijn Wouter
Research team(s)
Project type(s)
- Research Project
Effectiveness and efficiency of drugs used for substitution. (SUBST-OP)
Effectiveness of inpatient treatment programs for dually diagnosed patients.
Abstract
The investigation is preformed to support the `beleidsnota voor geestelijke gezondheidszorg' (Aelvoet & Vandenbroucke, 2001) and the `beleidsnota van de federale regering in verband met de drugsproblematiek' (2001). In the first one is stated that there is a need for specific attention to the crisis intervention and the treatment of dually diagnosed patients. In the second one is stated that the experiments with dually diagnosed patients have to be supported and evaluated. The dually diagnosed patients as well as the people who work with them are tested. The first part of the investigation focuses on the group of dually diagnosed patients. Dually diagnosed patients are patients with coexisting severe psychotic and substance use disorders. There are two questions that can be formulated: 1.Are double diagnosed patients effectively treated when they follow an residential integrated treatment program? 2.Is there a difference in efficiency between the residential integrated treatment and the residential non-integrated treatment program?Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
Cognitive functioning in patients with substance usedisorders.
Abstract
Prominent researchers argue that there is a clear relationship between the concept of impulsivity and substance use disorders. Since this personality trait covers a wide range of behaviors such as novelty seeking, behavioral undercontrol and disinhibition, it is important to investigate whether each component is equally important. The present research team investigates the role of the disinhibition component in abstinent alcoholics by means of questionnaires, go no go tasks and gambling tasks.Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
Cognitive and motor skills disorders for patients with depression.
Effectiveness of inpatient treatment programs for dually diagnosed patients.
Abstract
The investigation is preformed to support the `beleidsnota voor geestelijke gezondheidszorg' (Aelvoet & Vandenbroucke, 2001) and the `beleidsnota van de federale regering in verband met de drugsproblematiek' (2001). In the first one is stated that there is a need for specific attention to the crisis intervention and the treatment of dually diagnosed patients. In the second one is stated that the experiments with dually diagnosed patients have to be supported and evaluated. The dually diagnosed patients as well as the people who work with them are tested. The first part of the investigation focuses on the group of dually diagnosed patients. Dually diagnosed patients are patients with coexisting severe psychotic and substance use disorders. There are two questions that can be formulated: 1.Are double diagnosed patients effectively treated when they follow an residential integrated treatment program? 2.Is there a difference in efficiency between the residential integrated treatment and the residential non-integrated treatment program?Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project
Feasibility study on the evaluation of treatment services for patients with dual disorders/diagnosis.
Abstract
This study is a preliminary study for an overall evaluation study on treatment services for patients with dual disorders/diagnosis. Based on the existing scientific literature (guidelines, standards, protocols and study reviews) and our own experiences in national and international treatment programs, we will give an advice about the feasibility of an evaluation research in Belgium. After a thorough consideration of these research findings, we will then propose a research protocol. The evaluation research explores the effectiveness of different treatment programs for people with concurrent severe mental illness, in this case psychotic disorders, and substance use disorders. This means that we will extensively compare the standard care with the more intensive inpatient treatment programs, the so-called pilot treatment programs . Given their integrated treatment care and continuous care, we expect the pilot treatment programs to be superior to the standard care. This feasibility research comprises the following objectives: 1.A research on the feasibility of the evaluation research. A thorough investigation of official treatment guidelines and results of study reviews precedes our advice about the meaningful and practical feasibility of an evaluation research in Belgium. 2.Development of a research protocol. ·Conceptualisation of our target and control groups. ·Choice of independent and dependent variables. Each variable has to be described on the following levels: ·The individual patient. ·The socio-familial network. ·Social services. ·The treatment staff. ·Development of a specific methodology, for instance the definition of suitable instruments to measure the above mentioned variables. ·Proposition of a research procedure.Researcher(s)
- Promoter: Sabbe Bernard
Research team(s)
Project type(s)
- Research Project