Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade

Source
Journal for ImmunoTherapy of Cancer - ISSN 2051-1426-12:9 (2024) p. 1-15
Author(s)
    Nicola Principe, Amber-Lee Phung, Kofi L.P. Stevens, Omar Elaskalani, Ben Wylie, Caitlin M. Tilsed, Fezaan Sheikh, M. Lizeth Orozco Morales, Joel Kidman, Elly Marcq, Scott A. Fisher, Anna K. Nowak, Alison M. Mcdonnell, W. Joost Lesterhuis, Jonathan Chee

The MexTAg collaborative cross : host genetics affects asbestos related disease latency, but has little influence once tumours develop

Source
Frontiers in toxicology - ISSN 2673-3080-6 (2024) p. 1-19
Author(s)
    Scott A. Fisher, Kimberley Patrick, Tracy Hoang, Elly Marcq, Kiarash Behrouzfar, Sylvia Young, Timothy J. Miller, Bruce W.S. Robinson, Raphael Bueno, Anna K. Nowak, W. Joost Lesterhuis, Grant Morahan, Richard A. Lake

IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts