Abstract
Our team proposes an innovative project integrating a 3D patient-derived pancreatic microtumor model with multi-omics analyses to dissect molecular mechanisms of Pancreatic ductal adenocarcinoma (PDAC) at a single-cell, patient-specific level. We aim to understand the intercommunication and reprogramming between malignant cells, stromal cells, and macrophages during PDAC progression by applying single-cell RNA-sequencing, secretomics and proteomics. Additionally, we will employ our AI-driven high-throughput drug screening platform to visualize live-cell interactions and study cell behavior in context. This setup allows us to scrutinize the biological and therapeutic impact of identified communication pathways by testing new therapeutic strategies on our microtumor model, thereby monitoring cell-specific responses. This groundbreaking research could revolutionize our understanding of PDAC, paving the way for the identification of new therapeutic targets and the development of effective treatments.
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