Abstract
A diminished function of the upper limb, meaning difficulties in performing activities of daily living with the arm on the operated side, is highly prevalent, occurring in 50% of cases one year after breast cancer surgery. Post-treatment upper limb issues in breast cancer are complex and multifactorial, involving a variety of underlying mechanisms. In this longitudinal study, we aim to unravel the contribution of peripheral structural and mechanical properties of soft tissues (such as scar stiffness and fibrosis at the breast and shoulder region) to upper limb function in breast cancer survivors. Specifically, we will investigate the role of these factors both in the short term (i.e., within 1 month after surgery) and in the long term (i.e., more than 6 months after surgery and/or radiotherapy). Also, we will investigate whether soft tissue problems in the short term or prognostic for upper limb function in the long term. We will examine both objective and subjective measurements of upper limb function to comprehensively assess it. Unraveling the role of soft tissue factors for upper limb function at different time points after breast cancer surgery and gaining a complete understanding of upper limb function, both subjectively and objectively, is the first crucial step toward the development of prevention and treatment strategies for this issue after breast cancer. In the long term, our aim with this research is to improve the quality of life of women following breast cancer treatment.
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