Abstract
One of the major concerns in gastro-intestinal medicine is to understand how in the mucosal environment Neuro-Immune units can promote health or disease. Tackling these aspects requires genetic, cellular and molecular studies, which despite new technological progress in the last years, still remain to be elucidated.
Inflammatory Bowel Disease (IBD) are considered to be the wound that will never heal, which is characterized by a long chronic inflammatory pathology, and treatment strategies focuses on immune suppressive drugs or surgery, although these treatments are not curative. Nevertheless, the greater challenge remains particularly to target patients who do not respond or who lose response to treatment. To improve therapeutic design and implement new effective treatments of IBD, it will thus be necessary to increase the knowledge of how intestinal barrier homeostasis is supported by the microenvironment, constituting of stromal cells, and Neuro-Immune units. The main aim is to understand how different environments imprint on eNIU to induce inflammation or health/repair, and to identify the local inter- and intra-cellular networks and connections with the central nervous system.
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