Research Jean-Pierre Van geertruyden

Abstract

This PhD research addresses the significant challenge of vaccine hesitancy contributing to inadequate coverage and subsequent outbreaks of vaccine-preventable diseases in the Democratic Republic of Congo (DRC). Focusing on a remote area, specifically Boende, Tshuapa province, the study encompasses three crucial aspects. Firstly, it explores community perceptions of different adulthood and childhood vaccines, utilizing both qualitative and quantitative methods to comprehensively understand confidence levels and uptake, while identifying relevant socioeconomic factors. Secondly, the research assesses actual childhood vaccine coverage through blood tests, providing a more precise evaluation of measles and pertussis immunization. Thirdly, it investigates perceptions of vaccine clinical trial participation, with a particular emphasis on women of reproductive age, including an exploration of opinions on the exclusion of pregnant women from an Ebola vaccine trial. This multifaceted approach aims to provide essential insights for enhancing vaccination campaigns and strategies. The project's emphasis on comprehending the underlying reasons for vaccine hesitancy and low coverage is pivotal in addressing this global challenge, especially in remote regions. Furthermore, examining the perspectives on the exclusion of pregnant women from clinical trials contributes valuable information from women in a low-income country engaging in such trials. Employing a mixed-methods approach, this research seeks to provide a holistic understanding of the issue, empowering the development of more effective vaccination campaigns, public health strategies, and advocating for the equitable inclusion of pregnant women in clinical trials.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Fellow: Salloum Maha

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

Annually, almost 500,000 children under 5 years die from malaria in Africa. Timely access to effective antimalarial therapies is life saving as treatment with pre-referral rectal artesunate (RAS), followed by injectable artesunate and 3 days treatment with ACTs leads to an observed 96% reduction in mortality. Though recommended by the WHO for years, RAS deployment is very limited. The full treatment paradigm is not always feasible when access to primary healthcare facilities is limited due to lack of transport, non-availability of services, and cost. Rollout has recently been paused as outcomes data is incomplete in these contexts making the development of best practice recommendations challenging. Hence the relevance of the proposed study. The proposed project is an observational, non inferiority study in Zambia and DRC. Community Health Care Workers will identify/diagnose, treat and follow up patients with (severe) malaria as part of integrated community case management. We will compare the efficacy of a treatment regimen consisting of pre-referral RAS, then post-referral injectable artesunate, followed by three days of ACT versus a regimen consisting of RAS alone followed by three days of ACT in remote areas. We will compare recurrence rate between the two regimens at Day 28, the number of lives saved, the risk of generating drug resistance. We will assess and mitigate operational and institutional facilitators and barriers in all stakeholders (patients, caregivers, health care providers, regulators, malaria experts) and recommend sustainable policies for this remote context. This generated evidence will support policy development and implementation. The proposed consortium brings together vital experience in the rollout and deployment of rectal artesunate, study design and execution, social science, data collection and management, stakeholder engagement and translation of research results into clinical practice.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Co-promoter: Bastiaens Hilde

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

Onchocerciasis, caused by the parasite Onchocerca volvulus, is still endemic in Cameroon despite long-term annual community-directed treatment with ivermectin (CDTI). Low CDTI coverage and frequency (once a year) resulted in a high prevalence of onchocerciasis-associated morbidity (skin, eye, and neurological disease). Children infected with O. volvulus between the ages of 5-12 years are at risk of developing onchocerciasis-associated epilepsy. Moreover, O. volvulus infection during pregnancy induces "parasite tolerance" in the neonate and an increased risk to become infected with high parasitic loads, predisposing the child to develop onchocerciasis-associated morbidities. We hypothesize that maternal onchocerciasis has a negative impact on the neuro-cognitive development of the child. This will be investigated by recruiting nursing mothers with different exposures to onchocerciasis during pregnancy, and by monitoring the neurocognitive evolution of their children at 12 and 24 months of age. We also will evaluate a school-based ivermectin distribution strategy (adding to annual CDTI) to obtain six monthly intake of ivermectin by 5-12 year old children to prevent infection and ensuing morbidity. Understanding the impact of onchocerciasis on neurocognitive development during infancy and the possible benefits of an additional ivermectin dose in older children is expected to lead to interventions to preserve the intellectual capital of children in onchocerciasis-endemic regions.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Co-promoter: Colebunders Robert
• Co-promoter: Weckhuysen Sarah
• Fellow: Siewe Fodjo Joseph Nelson

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

Malaria is one of the most important infectious disease in Peru but now there is a National Malaria Elimination plan launched by the government. This plan requires from research-based evidence to adapt the strategies 'on the road' to malaria elimination scenario. Therefore, we aim to continue and deepen our efforts to provide relevant evidence for malaria elimination in Peru by promoting and empowering the partnership of Amazonian public universities and local, regional and national public health institutions. We seek to potentiate the multidisciplinary health-related research and outreach skills in these institutions, for them to later contribute to the good health and well-being of the most affected populations (indigenous and children) by malaria in Peru. We will assess multiple multidisciplinary approaches that could be implemented in the malaria elimination plan and provide educational information about malaria to the civil society and the affected population.

Researcher(s)

• Promoter: Delgado Ratto Chris
• Co-promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

The Master Epidemiology is unique in Flanders. Students gain the knowledge, skills and competences required to design and conduct epidemiological research to address the etiology, prevention, screening, diagnosis, and treatment of disease and to enhance or maintain health of people and populations. Three fields of epidemiology are covered in depth: infectious disease, clinical and environmental epidemiology. During the first year, the focus is on gaining in-depth knowledge in the fields of epidemiology, statistics and research methods. In addition, students become acquainted with the practice of epidemiology by attending seminars and workplace visits. In the second year, students expand their methodological knowledge in the course Advanced Methods in Epidemiology, learn how to convert theory into practice in the course Public Health, Policy and Practice, and focus on their own research for their Master's thesis.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Education Project

Abstract

BIONEXT will develop knowledge, tools, and guidance for mainstreaming biodiversity into policy making and provide concrete options on how to initiate, accelerate and upscale biodiversity relevant transformative change in society. It will deliver an innovative Nexus Modelling Framework that will integrate scenarios and pathways in a co-production process with stakeholders, while modelling interlinkages between biodiversity, water, food, energy, transport, climate, and health, and enabling simulation of the impacts of indirect and direct drivers on biodiversity. Through its database of transformative change cases, BIONEXT will involve policy- and decisionmakers and allows them to explore the concept of just transformative change. Plausible futures and desirable, nature-positive visions for Europe and multiple just transition pathways will be co-created in workshops and focus groups taking place in various cities around Europe. With the involvement of diverse stakeholders, the BIONEXT Pathways App will be delivered as a novel decision support tool that allows users to explore transformational building blocks, for formulating policies and implementation pathways for the biodiversity nexus. The results will contribute to science brokerage, capacity building and networking to IPBES, EU policymakers, and civil society.

Researcher(s)

• Promoter: Keune Hans
• Co-promoter: Springael Johan
• Co-promoter: Van geertruyden Jean-Pierre

Research team(s)

• Primary and interdisciplinary care Antwerp (ELIZA)

Project type(s)

• Research Project

Abstract

Despite adequate coverage of malaria intervention strategies in rural, remote areas, the elimination efforts vanished after some months, and residual malaria persists. Malaria importation might be playing a significant role in the maintenance of local transmission. From a fundamental perspective, this scenario reflects the metapopulation dynamics theory, where the parasite population's subdivisions are geographically dispersed but with limited interaction between the components. Events of extinction and recolonization give the maintenance of the metapopulation. For instance, after an adequate intervention, the parasite population might be diminished, but people returning to their villages carrying imported parasites may revert the effect. The present study aims to study the contribution of Plasmodium vivax metapopulation in the burden of residual malaria in villages sharing watersheds in the Amazon. We will unravel human mobility's role in the recolonization event by integrating epidemiological and travel data with the parasite population genetics. Our project is the first study to address P. vivax metapopulations as a significant challenge for elimination and seeks to develop a genomics platform that distinguishes among highly related parasites. The expected findings could provide crucial insights about a better design of intervention strategies.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Co-promoter: Delgado Ratto Chris

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

Malaria remains a major public health threat despite considerable progress on control in the past decade. We, and others, demonstrated that the burden of malaria in school aged children is substantial with significant consequences later on in life. Recent decreases in the malaria burden puts school-aged children increasingly more at risk for malaria. The mainstay for malaria control includes use of insecticide-treated nets (ITNs), indoor residual spraying (IRS), prompt diagnosis and treatment with an effective antimalarial drug . Malaria control interventions often target vulnerable populations, pregnant women and children under-fives or targets the population at large. Yet, these interventions have a weak coverage in school aged children and no malaria control interventions specifically target in school-aged children. In 2012, we started field work on this theme in DR Congo, a high malaria endemic setting, and proved that Intermittent preventive treatment in school children (IPTsc) is an efficacious and feasible intervention. These findings are confirmed by others and at present, we're conducting similar research in different sociocultural and epidemiological settings in Ethiopia and North East Tanzania. This PhD proposal will provide required additional information to translate evidence gathered in previous research into policy. We will identify models of within-host dynamics of Plasmodium falciparum that have been fitted to parasite density profiles from malaria therapy patients, and simulations of P. falciparum epidemiology fitted to field malariologic datasets from a large ensemble of settings across Africa. We will use this models to assess the relative and absolute contribution of schoolchildren (6-12 yrs) on malaria transmission in different malaria endemic settings taking into account the (effectiveness of) other interventions. We hypothese that school aged children, who represent 26.8% of the population though over 40% of both the malaria reservoir and burden, are a main driver of malaria transmission. Further, will the selected integrated mathematical models be used for predicting the epidemiologic and economic effects of IPTsc both at the individual and population level. The models will provide a unique platform for predicting both the short- and long-term effects of IPTsc on the burden of disease, allowing for the temporal dynamics of effects on immunity and transmission. We'll perform a sensitivity analyses taking into account adherence, school attendance rates, drug resistance rated and thus assess the impact of IPTsc on the malaria burden and transmission at population (i.c. impact on population level R0-rates). It should be mentioned that in the last decades school attendance rates have raised to over 95% in most LMICs (though drop-out rates are still substantial). Finally, the chosen model will obtain robust cost-effectiveness estimates for IPTsc delivery strategies in different eco-epidemiologic settings. We will be able to rank IPTsc amongst other health interventions and stipulate its contributing role to attain several Sustainable Development Goals' (SDGs). In parallel, this PhD-program will be involved in 4 case studies in 4 different settings (Ethiopia, Tanzania, DR Congo and Burkina Faso) in which we will assess the possible institutional implementation modalities. This health (and educational) system analysis is a key element. Many evidence based policy recommendations have suboptimal coverage or are, in practice not implemented as it is not clear which department or control program should take up this additional intervention, determine the possible supply channels, reporting, training programs and resources needed. We will also at least explore how an IPTsc could be the nucleus, together with existing helminth control programs, for a comprehensive (institutionalized) school health program (i.e. including immunization activities, oral health, vision screening, health education, etc…).

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Fellow: Manda Geoffrey

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

Background. Rapid diagnostic tests of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) is the cornestone to implement early case detection, contact tracing and isolation as part of the containment and controlling the spread of the deadly virus. The current diagnostic strategy recommended to identify COVID-19 suspects is to detect for the presence of viral RNA to SARS–CoV-2 in respiratory tract samples using molecular tests such as SARS–CoV-2 specific real time polymerase chain reaction (RT-PCR). However, in many resource constrained countries, there is a limited diagnostic facilities and access to molecular tests (RT-PCR) has been challenging. Such tests are usually done in centralized laboratories that are also face acute shortage of skilled laboratory staff, unreliable and weak transportartion network for patients and specimens as well as inefficient systems for result delivery. Recent development of the Gene Expert molecular Point-of-Care (POC) (Xpert Xpress SARS-CoV-2 test , Cepheid) for SARS-CoV-2 testing in the clinic with results delivery within hours of sample collection has been vital in resolving the turn around time (TAT).. The assay is an automated POC for qualitative detection of SARS-CoV-2 in nasopharyngeal swab, nasal wash, or aspirate specimens from suspected patients. GeneXpert are widely rolled up within national tuberculosis (TB) and HIV programmes across the continent. However, evaluation of the diagnostic accuracy of the newly introduced Gene Expert molecular POC SARS–CoV-2 assays and the feasibility of its intergration into the TB/HIV programme has not been evaluated in resource-constrained settings. It is anticipated that the presence of the Gene Expert platform and the introduction of SARS-CoV-2 detection will cater for timely detection of COVID-19 cases, avert fatalities, facilitate containment and lower the burden at the national reference labs. Study objective. This study aims to evaluate the diagnostic accuracy and effectiveness of POC VL in improving the availability of SARS-CoV-2 detection for COVID-19 patient management in decentralized healthcare facilities in resource-constrained settings in Africa. Furthermore, we will implement genomics surveillance of SARS-CoV-2 and other respiratory viruses to elucidate transmission, evolution, and geophaphical spread and inform pandemic control efforts and policies makers at local and regional level. Relevance. The rapid spread of SAR-CoV-2 necessitates urgent improvement in testing capacity at decentralized health facilities in the region. The recent advances in in vitro diagnostic (IVD) assays using Xpert Xpress SARS-CoV-2 (Cepheid) assay has potential to scale up and improve diagnostics in the region to support patients management and response strategies to curtail the spread of SARS-CoV-2. Thereferore, a quick evaluation and deployment of this tool will contribute toward controlling the transmission of SARS-CoV-2 in the population.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

This course offers a profound training of 6 weeks on the basic principles and methods of epidemiology. An in-depth study of medical statistics with appropriate statistical methods will be integrated with the main epidemiological content. Basic principles of qualitative methods will be explained. Introductory lectures on systematic reviews, health economics and cost-effectiveness are programmed. Throughout the whole course, each participant will have the opportunity to work with his/her own data set (or from the organisers if not available) under the guidance of experienced tutors. Each participant will receive a reader including necessary didactic materials (handouts, power point slides, articles, etc.). To offer a profound training of six weeks in research methods - on the basic principles and methods of epidemiology. - An in-depth study of medical statistics with appropriate statistical methods integrated in the main epidemiological content. - Basic principles of qualitatve methods - Introductory lectures on systematic reviews, health economics and cost-efectiveness

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

UC Leuven This course offers a profound training of 6 weeks on the basic principles and methods of epidemiology. An in-depth study of medical statistics with appropriate statistical methods will be integrated with the main epidemiological content. Basic principles of qualitative methods will be explained. Introductory lectures on systematic reviews, health economics and cost-effectiveness are programmed. Throughout the whole course, each participant will have the opportunity to work with his/her own data set (or from the organisers if not available) under the guidance of experienced tutors. Each participant will receive a reader including necessary didactic materials (handouts, power point slides, articles, etc.). To offer a profound training of six weeks in research methods - on the basic principles and methods of epidemiology. - An in-depth study of medical statistics with appropriate statistical methods integrated in the main epidemiological content. - Basic principles of qualitatve methods - Introductory lectures on systematic reviews, health economics and cost-efectiveness

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Co-promoter: Abrams Steven
• Co-promoter: Anthierens Sibyl

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

The phase out progamme is the period provided by VLIR-UOS to summarize and document all the accomplishments and lessons learned from the IUC Partner Programme. In this case the IUC-LIMPOPO that lasted for10 years

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

UC Leuven This course offers a profound training of 6 weeks on the basic principles and methods of epidemiology. An in-depth study of medical statistics with appropriate statistical methods will be integrated with the main epidemiological content. Basic principles of qualitative methods will be explained. Introductory lectures on systematic reviews, health economics and cost-effectiveness are programmed. Throughout the whole course, each participant will have the opportunity to work with his/her own data set (or from the organisers if not available) under the guidance of experienced tutors. Each participant will receive a reader including necessary didactic materials (handouts, power point slides, articles, etc.). To offer a profound training of six weeks in research methods - on the basic principles and methods of epidemiology. - An in-depth study of medical statistics with appropriate statistical methods integrated in the main epidemiological content. - Basic principles of qualitatve methods - Introductory lectures on systematic reviews, health economics and cost-efectiveness

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

The overal aim of this project is: to combat antimicrobial resistance (AMR) and health care associated infection in Uganda through improved education and training of health care professionals. We aim to reach this overall objective through 4 broad specific objectives: Objective 1. To have an actualized and locally relevant undergraduate curriculum for all health care professionals in the fields of AMR, antibiotic stewardship (ABS) and health care based infection prevention and control (IPC).

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Education Project

Abstract

This course offers a profound training of 6 weeks on the basic principles and methods of epidemiology. An in-depth study of medical statistics with appropriate statistical methods will be integrated with the main epidemiological content. Basic principles of qualitative methods will be explained. Introductory lectures on systematic reviews, health economics and cost-effectiveness are programmed. Throughout the whole course, each participant will have the opportunity to work with his/her own data set (or from the organisers if not available) under the guidance of experienced tutors. Each participant will receive a reader including necessary didactic materials (handouts, power point slides, articles, etc.).

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

The overall aim of EBOVAC3 is to support an essential part of remaining clinical and manufacturing activities required for licensure in the European Union (EU) and the United States (US) of a candidate heterologous prime-boost prophylactic vaccine regimen against Ebola virus disease.

Researcher(s)

• Promoter: Van Damme Pierre
• Co-promoter: Revets Hilde
• Co-promoter: Van geertruyden Jean-Pierre

Research team(s)

• Centre for the Evaluation of Vaccination (CEV)

Project type(s)

• Research Project

Abstract

Almost 90% of deaths from HPV-related invasive cervical cancer (ICC) worldwide occur in developing countries and ICC is a main cause of morbidity and mortality in Sub-Saharan Africa (SSA). However, in SSA, we observe a significant lack of ICC knowledge among health care workers. Furthermore, academic ICC expertise is also completely missing, undermining any effort to strengthen the health care capacities. Local academic expertise is also vital for National policy makers and public opinion. In 2013, we established the WAKA network to train African based researchers till a post-doc level, to stimulate international South South collaboration and to support local laboratory facilities (www.wakahpvafrica.com). Several students from SSA are in a doctoral trajectory and the WAKA network gained significant recognition (i.e. WHO). This proposal wants to continue, deepen and expand this network until a level of self-sustainability.

Researcher(s)

• Promoter: Bogers John-Paul
• Co-promoter: Jacquemyn Yves
• Co-promoter: Van geertruyden Jean-Pierre

Research team(s)

• Laboratory of cell biology and histology

Project website

Project type(s)

• Research Project

Abstract

Malaria burden severely affects the population living in the Peruvian Amazon, which is also affected by low-living conditions. Currently, the Peruvian government has launched the Malaria Elimination program in the Amazon and requires evidence-based research to improve its program. UNAP is the main university in the Peruvian Amazon and is looking to become a key role player on the development of the region by supporting this elimination initiative. The first steps of supporting UNAP becoming more active on research were initiated through a triangular collaboration between UNAP, UPCH and UAntwerp in 2016 (VLIR SI). Here by, we intend to continue and strengthen this collaboration by actively developing educational and research capacities on epidemiology, data analysis and population genetics at UNAP. Constant training through students/professors exchange, courses given by UAntwerp/UPCH professors at UNAP and joint research related to malaria elimi-nation tools encircle the strategy proposed on this VLIR TEAM project.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

Despite the recent gains, malaria still remains the major cause for mortality and morbidity among children. Further, recent advancements in malaria control is associated with an increased burden of malaria in school children due to delayed in acquisition of protective immunity. Co-morbidities with soil transmitted helminths (STH) and i.e malnutrition compounds the problem even further. Intermittent preventive treatment in school children (IPTc) in school children may be an efficient and effective control strategy. However, today Sulfadoxine-pyrimethamine monotherapy is the only recommended drug to be used as IPT despite the widespread of SP resistant strains. Therefore, there is an urgent need to evaluate alternative drugs to be used for IPTc. Therefore, we'll conduct a clinical trial to compare the efficacy and safety of IPTc using dihydroartemisinin plus piperaquine (DHA-PQ), SP-PQ, SP alone and control group in high SP-resistance setting. Further, using a mixed design methods, we will assess the acceptability, (cost-)effectiveness and feasibility of this strategy as part of a more comprehensive school health package. In combination other proven school health control activities (i.e. addressing chronic and acute malnutrition, optimizing strategies for interrupting geo-helminths).

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

This project is the third phase of a long term, institutional cooperation programme between a number of Flemish universities and the public university 'Université du Burundi', based in Bujumbura. The programme spans a period of ten years in total, ending with this third phase, and covers five different areas of scientific cooperation, including law, agronomy, physics, medecine and ICT. In addition, the project contributes to capacity-building of the partner university in its research capacities, i.a. through the establishment of a Doctoral School (Ecole doctorale). The project is part of the VLIR-UOS country programme with Burundi.

Researcher(s)

• Promoter: Vandeginste Stef
• Co-promoter: Van geertruyden Jean-Pierre

Research team(s)

• Development processes, actors and policies

Project type(s)

• Research Project

Abstract

The overall research objective of the SPICES project is to implement and evaluate a comprehensive CVD prevention and control program in five settings: a rural & semi-urban community in a low-income country (Uganda), middle income (South Africa) and vulnerable groups in three high-income countries (Belgium, France and United Kingdom) as well as to identify and compare the barriers and facilitators across study contexts. The project will be evaluated using a mix of qualitative and quantitative methods. At the beginning of the project, we will conduct baseline assessments including literature reviews, formative studies, household surveys (where feasible) and learn lessons from other projects to understand healthcare and lifestyle practices, barriers, and facilitators. A costeffectiveness and cost benefit analysis will be included. In addition, the teams will conduct site exchanges visits to learn from each other and organise policy dialogues to ensure sustainability and maximise impact of the interventions.

Researcher(s)

• Promoter: Bastiaens Hilde
• Co-promoter: Anthierens Sibyl
• Co-promoter: Van geertruyden Jean-Pierre
• Co-promoter: Van Royen Paul

Research team(s)

• Primary and interdisciplinary care Antwerp (ELIZA)

Project website

Project type(s)

• Research Project

Abstract

The present project seeks to fulfil the academic capabilities of UNAP by improving quality of research and education. The project relies in the formation of a triangular structure of academic and educational collaboration between the UNAP (public university, academically weak but with high potential as key player in the development of Amazon population), UPCH (well-stablished university will lead UNAP on the project) and UA (supporting the capacity building). The VLIR Sl project will strengthen the academic and operational capacities on molecular epidemiology through active coaching and training in epidemiology, biostatistics and population genetics. From the start of the project UA will provide support to the Peruvian partners on population genetics analysis for which a computer cluster and the respective training will be provided in Peru.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

La RD Congo et l' l'Université de Lubumbashi (UNILU) souffrent d'une grave carence du personnel compétent en recherche scientifique clinique de qualité internationale et en relève académique; surtout en pathologies infectieuses. Ce projet initial vise à créer une unité de recherche clinique à la Faculté de médecine de l'UNILU. Pour s'y faire, ce projet permettra la formation du personnel académique dans la conduite des recherches cliniques mais aussi en épidémiologie et statistiques. La formation du personnel scientifique se concrétisera par la réalisation de 7 projets de recherches sélectionnés de manière compétitive avec un sup-port adéquat de laboratoire. Les récipiendaires bénéficieront des cours ad hoc et d'un encadrement des professeurs de l'UA, de l'UNIKIN et de l'UNILU afin de pouvoir continuer avec leur projet de recherche jusqu'au niveau doctoral..

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Co-promoter: Bastiaens Hilde
• Co-promoter: Bervoets Lieven
• Co-promoter: Bogers John-Paul

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

Notre projet a pour but d'aider les chercheurs de l'Université de Kisangani dans leurs efforts d'identifier la cause de l'épilepsie des rivières qui est un problème de santé publique majeur, récemment détecté dans la Province Orientale dans une région hyper-endémiques pour l'onchocercose (maladie parasitaire qui cause la « cécité de rivières ») et de développer une stratégie pour diminuer la souffrance et la stigmatisation lié à l'épilepsie des rivières.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Co-promoter: Colebunders Robert

Research team(s)

Project type(s)

• Research Project

Abstract

Background: Nodding syndrome (NS) is a life threatening neurological disorder, currently affecting an increasing number of children between 5 and 15 years in South Sudan, Northern Uganda and Southern Tanzania. NS is characterized by head-bobbing spells often followed by other types of seizures, developmental retardation and growth faltering. In the affected regions, NS is becoming a major public health problem with high morbidity and mortality rates and with severe social-economic implications. Despite detailed investigations in a limited number of Ugandan children, the aetiology and pathogenesis of NS remains unknown. Aside from questions regarding the aetiology, questions regarding the disease incidence, prevalence and long-term course remain outstanding. Proposed study: It is proposed to conduct an integrate program combining a case- control design with a detailed descriptive study using a phased approach. In the first phase a pathogen discovery programme will be applied on a limited number of NS patients and a group of controls using state of the art next generation sequencing and microarray-based methods on samples obtained from children and black flies. The focus of the second phase of the study will depend, in part, on the outcome of first phase: If a possible pathogen is identified the focus in the second phase will be on further identification of this pathogen. If no pathogen is identified, a detailed descriptive aetiology studies will be started using a case- control design and investigating all possible aetiologies previously indicated. Irrespective of the outcome of phase 1, in the second phase a surveillance study will also be started of all NS cases in the four most affected counties of South Sudan, next to a long term follow up of a selected group of NS cases and controls. This 3 years program will be conducted in close collaboration with South Sudanese, Dutch and Belgium NS and paediatric research experts and will be built on existing NS research and support activities already in place in South Sudan. Expected outcome: There is a significant chance that the true aetiology and the risk factors for NS will be identified and that the NS epidemiology in South Sudan will be clarified with respect to incidence, prevalence and disease progression. In addition, the study will create a platform for treatment intervention studies and will inform local health authorities how to improve their disease management and prevention strategies.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Co-promoter: Colebunders Robert

Research team(s)

Project type(s)

• Research Project

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre
• Co-promoter: Bogers John-Paul
• Co-promoter: Jacquemyn Yves
• Co-promoter: Maes Louis

Research team(s)

Project type(s)

• Research Project

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

The final aim of this research will be to provide new strategies and tools to detect schistosomiasis in a context in which the estimated current prevalence is below 10%. This project will provide a proof of principle of new possible approaches in alternative to blanket mass drug administration in view of the elimination of schistosomiasis and possibly other worm infections in Burundi.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

Despite evidence based policies, drug availability for most common diseases varies dramatically from place to place. Furthermore, health professionals have acquired limited competences to manage an operational district after graduation. Through qualitative and quantitative research projects we will assess various human behavioural aspects which may affect directly or indirectly the genesis and spread of drug resistance. Equally, we will assess the quality and quantity of the medicines availabele and assess the level of drug resistance of circulating pathogens.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

• Global Health Institute (GHI)

Project type(s)

• Research Project

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

This project represents a formal research agreement between UA and on the other hand Erasmus Mundus. UA provides Erasmus Mundus research results mentioned in the title of the project under the conditions as stipulated in this contract.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

The overall aim of the proposed staff exchange program is to establish a long lasting collaboration between South African and European research teams involved in HIV coinfection research. This effort ultimately should lead to new ways to improve the care/treatment for patients with HIV co-infections and to decrease the high mortality among persons with HIV infection in Africa.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

The overall goal of the project is to identify if first line ACT can be safely and efficaciously used to retreat children with recurrent malaria occurring beyond 14 days after initial treatment and consequently preserve quinine for severe malaria treatment.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

We will compare, in a non-inferiority, randomised, controlled trial, in Congolese children under 5 years of age, the efficacy of ASAQ to quinine as a rescue treatment for uncomplicated P. falciparum malaria. Additionally, given the key role of humoral immunity in protecting against malaria, we will assess antibody levels to merozoite antigens and VSAs in Congolese children under 5 with uncomplicated malaria and their association with anti-malarial treatment outcome.

Researcher(s)

• Promoter: Van geertruyden Jean-Pierre

Research team(s)

Project type(s)

• Research Project

Abstract

This project represents a formal research agreement between UA and on the other hand VLIR. UA provides VLIR research results mentioned in the title of the project under the conditions as stipulated in this contract.

Researcher(s)

• Promoter: Colebunders Robert
• Co-promoter: de Deckere Eric
• Co-promoter: Goossens Herman
• Co-promoter: Meulemans Herman
• Co-promoter: Van geertruyden Jean-Pierre
• Co-promoter: van Sprundel Marc

Research team(s)

Project type(s)

• Research Project