Research team
Prolylcarboxypeptidase in body weight control: a role for peripheral peptide cleavage?
Abstract
In a first part of the project we will investigate the protein expression and enzymatic activity of PRCP in the circulation. Thereafter, we will perform in vitro experiments to study the cleavage of apelin and enterostatin by PRCP and compare cleavage efficiency with other known PRCP substrates. A third objective is to investigate apelin and enterostatin cleavage by PRCP in vivo and to find out whether PRCP influences their effect on body weight and metabolism. Understanding how peptide hormones are degraded by PRCP may open new approaches for therapeutic intervention.Researcher(s)
- Promoter: De Meester Ingrid
- Co-promoter: Lambeir Anne-Marie
- Fellow: Kehoe Kaat
Research team(s)
Project type(s)
- Research Project
Prolylcarboxypeptidase in body weight control: a role for peripheral peptide cleavage?
Abstract
In a first part of the project we will investigate the protein expression and enzymatic activity of PRCP in the circulation. Thereafter, we will perform in vitro experiments to study the cleavage of apelin and enterostatin by PRCP and compare cleavage efficiency with other known PRCP substrates. A third objective is to investigate apelin and enterostatin cleavage by PRCP in vivo and to find out whether PRCP influences their effect on body weight and metabolism. Understanding how peptide hormones are degraded by PRCP may open new approaches for therapeutic intervention.Researcher(s)
- Promoter: De Meester Ingrid
- Co-promoter: Lambeir Anne-Marie
- Fellow: Kehoe Kaat
Research team(s)
Project type(s)
- Research Project