Kv7 channel activation reduces brain endothelial cell permeability and prevents kainic acid-induced blood-brain barrier damage
Source
American journal of physiology : cell physiology - ISSN 0363-6143-326:3 (2024) p. C893-C904
In silico assisted identification, synthesis, and In vitro pharmacological characterization of potent and selective blockers of the epilepsy-associated KCNT1 channel
Source
Journal of medicinal chemistry - ISSN 0022-2623-67:11 (2024) p. 9124-9149
Gain of function due to increased opening probability by two KCNQ5 pore variants causing developmental and epileptic encephalopathy
Source
Proceedings of the National Academy of Sciences of the United States of America - ISSN 0027-8424-119:15 (2022) p. 1-10
Beyond retigabine : design, synthesis, and pharmacological characterization of a potent and chemically stable neuronal Kv7 channel activator with anticonvulsant activity
Source
Journal of medicinal chemistry - ISSN 0022-2623-65:16 (2022) p. 11340-11364
KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism
Source
EBioMedicine - ISSN 2352-3964-81 (2022) p. 1-15