Luc Van Nassauw technological manager

Research Luc Van Nassauw

Research team

Role of purinergic signaling in the pathophysiology of human chronic upper airway inflammation. 01/01/2010 - 31/12/2013

Abstract

In this project we aim to characterize the biological properties of purinergic pathways in human inflammatory cells in the context of their contribution to the development and persistence of chronic human inflammatory airway diseases.

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  • Research Project

The putative effect of corticostatin and neuropeptides belonging to the CRF-family on the interaction between visceral afferents, mast cells and dendritic cells during intestinal inflammation. 01/01/2008 - 31/12/2011

Abstract

The aim of this project is (1) to verify whether CRF, UCN2 and UCN3, in addition to UCN1 and CST, also have anti-inflammatory effects on intestinal inflammation; (2) to determine, on the one hand, the effect of these neuropeptides on the neuroimmune interaction during inflammation and, on the other hand, the importance of this effect in the therapeutical effects of these neuropeptides; and (3) to examine which receptors are effectively involved in this process.

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  • Research Project

Characterisation of enteric neurons during the development of the zebrafish, Danio rerio. 01/01/2008 - 31/12/2009

Abstract

The morphological, neurochemical and electrophysiological characteristics of the enteric neurons during the development of the zebrafish gut will be unravelled to define the neuronal types of the enteric nervous system. This knowledge is necessary to analyse the functional changes in the enteric nervous system of zebrafish mutants which are used in studies of gastrointestinal diseases.

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  • Research Project

Purinoceptors in the enteric nervous system, and their function in the pathogenesis of intestinal suffering during inflammation. 01/05/2005 - 31/12/2006

Abstract

Using different morphological (multiple immunofluorescence, confocal microscopy,¿) and molecular biological techniques (in situ hybridisation, Real-Time PCR,¿), the distribution of P2 purinoceptors, playing a key role in transducing mechanosensory signals, in the murine gastrointestinal tract is studied during normal physiological conditions and during gastrointestinal inflammation (i.e. intestinal schistosomiasis).

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  • Research Project

In vitro study of the neuro-immune interaction between mucosal mast cells and extrinsic sensory, primary afferent neurons in mice infected with Schistosoma mansoni. 01/01/2003 - 31/12/2004

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  • Research Project

The mouse as a study object for the examination of the pathogenesis of intestinal suffering by schistosomiasis: a morphological analysis of the enteric nervous system. 01/01/1999 - 31/12/2000

Abstract

Using a recent tracer technique within organotypic cultures, combined with immunocytochemical and in situ hybridization methods, the effects of schistosomiasis on the intrinsic component of the enteric nervous system, i.e. on the course of intrinsic nerve tracts and on the neurochemical characteristics of neurons, and also on the expression of cyto- and chemokines in non-neuronal cells, will be morphologically analyzed.

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    • Research Project

    Bridging credit for cofinancing the post doctoral fellowship of Luc Van Nassauw. 01/10/1998 - 30/09/1999

    Abstract

    Immunohistochemical and in situ hybridisation study of the enteric innervation of the mouse under normal and inflammatory conditions.

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      • Research Project

      Study of the molecular mechanism of programmed apoptosis and the balance between celproliferation and apoptosis during oogenesis and the early development of the embryo. 01/01/1998 - 31/12/1999

      Abstract

      In recent years the presence, the spatial distribution and the possible role of apoptotic cells in the adult quail ovary and in the young chicken embryo have been thoroughly studied. In this study the molecular mechanism of apoptotic cell death is approached in both systems, and the balance between cell proliferation and cell death in the early chicken embryo is made up.

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        • Research Project

        01/10/1995 - 30/09/1998

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          • Research Project

          Role of apoptosis in oögenesis and the early development of the embryo. 01/05/1995 - 30/04/1997

          Abstract

          Apoptosis (programmed cell death) is a general feature during the development of metazoa. The aim is to extend a former, limited study which showed that apoptosis occurs in the very early stages of the development and during oogenesis. This localisatory study is further extended and the factors which cause this cellbiological process are investigated.

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            • Research Project

            01/10/1993 - 30/09/1994

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              • Research Project

              01/10/1992 - 30/09/1995

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                • Research Project