Abstract
This PhD research addresses the significant challenge of vaccine hesitancy contributing to inadequate coverage and subsequent outbreaks of vaccine-preventable diseases in the Democratic Republic of Congo (DRC). Focusing on a remote area, specifically Boende, Tshuapa province, the study encompasses three crucial aspects. Firstly, it explores community perceptions of different adulthood and childhood vaccines, utilizing both qualitative and quantitative methods to comprehensively understand confidence levels and uptake, while identifying relevant socioeconomic factors. Secondly, the research assesses actual childhood vaccine coverage through blood tests, providing a more precise evaluation of measles and pertussis immunization. Thirdly, it investigates perceptions of vaccine clinical trial participation, with a particular emphasis on women of reproductive age, including an exploration of opinions on the exclusion of pregnant women from an Ebola vaccine trial. This multifaceted approach aims to provide essential insights for enhancing vaccination campaigns and strategies. The project's emphasis on comprehending the underlying reasons for vaccine hesitancy and low coverage is pivotal in addressing this global challenge, especially in remote regions. Furthermore, examining the perspectives on the exclusion of pregnant women from clinical trials contributes valuable information from women in a low-income country engaging in such trials. Employing a mixed-methods approach, this research seeks to provide a holistic understanding of the issue, empowering the development of more effective vaccination campaigns, public health strategies, and advocating for the equitable inclusion of pregnant women in clinical trials.
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