Research team
Expertise
As a scientific research manager of the Infla-Med Research Consortium of Excellence, I continuously explore innovative and multidisciplinary research collaborations within and outside the consortium. For this, I identify funding possibilities and support the process of writing new fundamental and applied preclinical research proposals for the Infla-Med consortium. I am also involved in the project management of large international projects (MSCA-ITN, ERA.Net, IMI,...). This research consortium of Excellence at the University of Antwerp performs fundamental and translational research into targets for the treatment of inflammatory diseases by using a multidisciplinary approach.
Design and synthesis of metacaspase inhibitors as potential lead compounds for antiparasitic chemotherapeutics.
Abstract
This research evolves around a cysteïne protease of Trypanosoma brucei, metacaspase (MCA), of which the function is currently still unknown. Metacaspase has already been tested as drug target, but no MCA inhibitors are known at present. The project focuses on a rational design and synthesis of inhibitors in order to establish a structure-activity-relationship. In a next step, optimization of the achieved inhibitors will be examined. Our final goal is to develop chemically stable inhibitors with a high potency and maximal selectivity with respect to human caspases.Researcher(s)
- Promoter: Augustyns Koen
- Fellow: Berg Maya
Research team(s)
Project type(s)
- Research Project
Synthesis and biological evaluation of nucleoside hydrolase inhibitors as trypanocidal compounds.
Abstract
Researcher(s)
- Promoter: Augustyns Koen
- Co-promoter: Haemers Achiel
- Fellow: Berg Maya
Research team(s)
Project type(s)
- Research Project
Serine proteases as targets in anti-parasitic drug design.
Abstract
Researcher(s)
- Promoter: Augustyns Koen
- Fellow: Berg Maya
Research team(s)
Project type(s)
- Research Project