Abstract
Very recently, 3 very active compounds, all with a benzo[j]phenanthridine-7,12-dione skeletal structure, against the causative agent of tuberculosis, Mycobacterium tuberculosis, were discovered. However, since the current syntheses for these compounds are inadequate to prepare sufficient quantities for further biotesting and elucidation of the mechanism of action, a number of new, efficient approaches are presented in this project . Furthermore, it is the intention to develop new syntheses of various substituted benzo[j]phenanthridine-7,12-diones, and to test these compounds for their anti-mycobacterial activiteit with the aim to achieve more active and less toxic analogues.
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