Research team
Expertise
All modern one- and multidimensional NMR techniques for the identification of (organic) chemical compounds.
Support maintenance scientific equipment (Organic synthesis).
Abstract
Researcher(s)
- Promoter: Dommisse Roger
- Promoter: Maes Bert
Research team(s)
Project type(s)
- Research Project
Multimar: Multidisciplinary magnetic resonance.
Abstract
This is a fundamental research project financed by the Research Foundation - Flanders (FWO). The project was subsidized after selection by the FWO-expert panel.Researcher(s)
- Promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Microwave assisted synthesis of renewable raw materials from triglycerides.
Abstract
Study of the microwave assisted synthesis of renewable raw materials from triglycerides with specific attention for new catalysts and catalyst-free processes. These processes reduce the amount of waste products and they could also be the start of the development of compact industrial production processes (flow-through microwave reactors).Researcher(s)
- Promoter: Maes Bert
- Co-principal investigator: Tavernier Serge
- Co-promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Structure elucidation of synthetic compounds and natural products by NMR and LC-NMR spectroscopy.
Abstract
This project represents a research contract awarded by the University of Antwerp. The supervisor provides the Antwerp University research mentioned in the title of the project under the conditions stipulated by the university.Researcher(s)
- Promoter: Augustyns Koen
- Co-promoter: Dommisse Roger
- Co-promoter: Maes Bert
- Co-promoter: Pieters Luc
Research team(s)
Project type(s)
- Research Project
Anoxia resistance in vertebrates: metabolomics of brains en hearts that never stop.
Abstract
The crucian carp can survive for weeks in total anoxia, amongst others because of a unique anaerobic pathway producing ethanol. During this period brain and heart remain fully functional. This study compares the 'metabolomics' of the main organs of the anoxic crucian carp with those of the closely related, but not anoxia resistent, common carp. New methodologies for NMR and data analaysis will ne optimised.Researcher(s)
- Promoter: Dommisse Roger
- Co-promoter: De Boeck Gudrun
- Co-promoter: Laukens Kris
Research team(s)
Project type(s)
- Research Project
Magnetic Resonance in materials, chemical and biomedical sciences.
Abstract
This is a fundamental research project financed by the Research Foundation - Flanders (FWO). The project was subsidized after selection by the FWO-expert panel.Researcher(s)
- Promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Application of advanced and diffusion based Magnetic Resonance techniques as a new tool to investigate nanoparticles and brain biochemistry.
Abstract
Researcher(s)
- Promoter: Dommisse Roger
- Co-promoter: Van Der Linden Annemie
Research team(s)
Project type(s)
- Research Project
Study of the Transesterification of Triglycerides with Mono-alcohols under Microwave Heating.
Abstract
Study of the transesterification of triglycerides with mono-alcohols under microwave heating, aiming increased conversion and reaction speed, as well as the use of lower (up to zero) concentration of catalyst. Realization of these targets would lead to cheaper biodiesel production, to cheaper fatty acid esters of higher alcohols (higher added value), to a reduction of effluents during downstream processing and to more compact industrial production processes (flow-through reactors).Researcher(s)
- Promoter: Maes Bert
- Co-promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Interuniversity 700 MHz field NMR infrastructure as a high technological research instrument in biotechnological, chemical and materials sciences.
Synthesis of Aminoalkylamino-substituted Neocryptolepine Analogues: Valorisation of the Cryptolepine Alkaloids as Antimalarials.
Abstract
The aim of this project is the synthesis of aminoalkylamino substituted neocryptolepine derivatives. Herewith we aim to decrease the cytotoxicity and to increase the antiplasmodial activity of the natural product neocryptolepine. These substituted neocryptolepines will be prepared from the corresponding chloroneocryptolepines using a Buchwald-Hartwig amination. 1-, 2-, 3-, 4-, 7-, 8-, 9-, 10- and 11-chloroneocryptolepine will be synthesized via respectively a 'condensation - Graebe-Ullmann', a 'Palladium catalyzed amination - arylation' and a 'Friedel-Crafts acylation - intramolecular nitrene C-H insertion' approach.Researcher(s)
- Promoter: Maes Bert
- Co-promoter: Dommisse Roger
- Fellow: Hostyn Steven
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Lemiere Guy
- Co-promoter: Dommisse Roger
- Co-promoter: Maes Bert
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Dommisse Roger
- Co-promoter: Jonckers Tim
Research team(s)
Project type(s)
- Research Project
Advanced NMR applications in the materials, chemical and biomedical sciences.
Submitting novel chemical compounds in accordance with the research strategy defined by the team.
Abstract
Researcher(s)
- Promoter: Lemiere Guy
- Co-promoter: Dommisse Roger
- Co-promoter: Maes Bert
Research team(s)
Project type(s)
- Research Project
Enzymatic kinetic resolution of racemic dihydrobenzofuran neolignans.
Abstract
Dihydrobenzofuran neolignans are known to be effective against certain forms of cancer. Biological studies pointed out that only one enantiomer posesses this activity. Therefore it will be tried to synthesize enantiomerically pure or enriched compounds using enantioselective enzymatic reactions.Researcher(s)
- Promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Synthesis and structure elucidation of cryptolepine en neocryptolepine-derivatives as possible antimalarial compounds.
Abstract
Contrary to what is often thought, malaria is on its way to a revival. Because of the growing resistance of the malaria parasites against the known chemotherapeutica, there is a constant demand for new and more effective compounds. Cryptolepine and Neocryptolepine are two lead compounds whith a proven antimalarial activity. The goal of this research project is the synthesis and structure elucidation of new derivatives of these two compounds.Researcher(s)
- Promoter: Dommisse Roger
- Fellow: Jonckers Tim
Research team(s)
Project type(s)
- Research Project
RAFO: replacement of console NMR spectrometer.
Abstract
High resolution NMR is used for structure elucidation of organic compounds. The console of our Varian Unity-400 NMR spectrometer had to be replaced in order to enable us to apply newer pulse sequences. The old console was outdated as well as unreliable.Researcher(s)
- Promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Multidisciplinary spectroscopic research of organic materials and biomolecules.
Abstract
In the proposed concerted action fundamental properties of synthetic organic compounds and biomolecules will be studied, giving emphasis to the study of their molecular and electronic structure with the aid of the following spectroscopic methods: electron spin resonance (ESR), mass spectrometry (MS), nuclear magnetic resonance (NMR) and vibration spectroscopy (IR-absorption and Raman diffraction). The research team includes four laboratories with state-of-the-art instrumentation and internationally recognized expertise with regard to the above mentioned spectroscopic methods, and two associated laboratories which are active in a complementary way in the preparation and evaluation of the materials studied. The research will focus on two classes of materials: (i) Biomolecules, more specifically, carbohydrate, lipid-like and polyphenolic compounds. These biomolecules show in general a high natural complexity with regard to their structure as well as their function. They show a broad range of biological activities, have already resulted in useful pharmaceuticals and are still important in the development of the latter. Some of these biomolecules enjoy a current interest with regard to prevention against degenerative diseases and cancer. (ii) Aromatic oligomers and polymers with electrical and optical applications. Some technologically relevant examples are conducting polymers, - with chemical detectors as a specific application -, and polymeric light-emitting diodes (LED's). In the synthesis of these materials a large variation of compounds can be prepared and in some cases structure determination of the molecules is desirable. In addition, the determination and engineering of electronic and other functional properties is important for the applicability of the materials.Researcher(s)
- Promoter: Goovaerts Etienne
- Co-promoter: Claeys-Maenhaut Magda
- Co-promoter: Dommisse Roger
- Co-promoter: Van Der Veken Benjamin
Research team(s)
Project type(s)
- Research Project
NMR and quantum-chemical study of the structure and electronical substitution effects in quaternary benzo[c]phenanthridine and protoberberine alkaloids, their bases and derivatives.
Abstract
Nitrogen-15 NMR and quantum-chemical methods will be implemented in order to facilitate structural research of alkaloid derivatives with known biological activity but uncertainties on structural aspects.Researcher(s)
- Promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Synthesis and structure elucidation of cryptolepine en neocryptolepine-derivatives as possible antimalarial compounds.
Abstract
Contrary to what is often thought, malaria is on its way to a revival. Because of the growing resistance of the malaria parasites against the known chemotherapeutica, there is a constant demand for new and more effective compounds. Cryptolepine and Neocryptolepine are two lead compounds whith a proven antimalarial activity. The goal of this research project is the synthesis and structure elucidation of new derivatives of these two compounds.Researcher(s)
- Promoter: Dommisse Roger
- Fellow: Jonckers Tim
Research team(s)
Project type(s)
- Research Project
NMR study of the relaxational behaviour of ethylene-propylene copolymers.
Abstract
This project aims at the NMR study of ethylene-propylene copolymers, esp. the investigation of the connection between the data at a molecular level and the macroscopic features measured by means of several physical and mechanical methods.Researcher(s)
- Promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
In-vivo non-invasive quantification of tissue and organ perfusion using Magnetic Resonance Imaging
Abstract
Within this project we aim to develop an in-vivo non invasive method which allows to determine blood perfusion in tissues using Magnetic Resonance Imaging techniques. The ultimate goal is to implement these techniques to realise blood pefusion measurements in the rat brain and to measure tumor perfusion in a tumor animal model in nude mice.Researcher(s)
- Promoter: Dommisse Roger
- Co-promoter: Van Der Linden Annemie
Research team(s)
Project type(s)
- Research Project
Vision.
Abstract
Researcher(s)
- Promoter: Van Dyck Dirk
- Co-promoter: Dommisse Roger
- Co-promoter: Jacob Willem
- Co-promoter: Lowen Bob
- Co-promoter: Raman Erik
- Co-promoter: Rousseeuw Peter
- Co-promoter: Van Espen Piet
- Co-promoter: Van Landuyt Joseph
- Co-promoter: Verschoren Alain
Research team(s)
Project type(s)
- Research Project
Study of primary and secondary human brain tumors.
Abstract
A correlation study will be done between histology and NMR imaging of post mortem specimens of brain containing primary or secondary tumors. It will be attempted to improve the imaging protocol in order to evaluate the possibility to discriminate invaded from non-invaded oedema.Researcher(s)
- Promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Nuclear magnetic resonance imaging and spectroscopy of an animal model for multiple sclerosis in the rat.
Abstract
In an animal model for MS in the rat, we will determine the clinical and pathological significance of 1) lesions demonstrated in the central nervous system by means of NMR imaging and 2) the biochemical changes that can be observed in these lesions by means of NMR.Researcher(s)
- Promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Van Der Linden Annemie
- Co-promoter: Dommisse Roger
Research team(s)
Project type(s)
- Research Project
Nuclear magnetic resonance spectroscopy for in vivo determination of metabolic stress indicators in aquatic invertebrates and vertebrates.
Abstract
The energy status can be considered as a measure for the physiological fitness of an organism. 31P NMR spectroscopy allows to determine the energy status of a testorganism (carp, mussel) submitted to stress (hypoxia, anoxia) and this in an non-invasive and in vivo manner. Chemical stressors (PCB, heavy metals...) will have a measurable influence on the energy status of the test animal and this influence will in its turn function as a measure for the severity of the environmental stress.Researcher(s)
- Promoter: Dommisse Roger
- Co-promoter: Blust Ronny
- Co-promoter: Decleir Walter
- Co-promoter: Van Der Linden Annemie
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Dommisse Roger
- Fellow: Plaum Ludwig
Research team(s)
Project type(s)
- Research Project