Discovery of a series of macrocycles as potent inhibitors of Leishmania infantum

Source
Journal of medicinal chemistry - ISSN 0022-2623-67:20 (2024) p. 18170-18193
Author(s)
    Federico Riu, Larissa Alena Ruppitsch, Duc Duy Vo, Richard S. Hong, Mohit Tyagi, An Matheeussen, Sarah Hendrickx, Vasanthanathan Poongavanam, Guy Caljon, Ahmad Y. Sheikh, Peter Sjo, Jan Kihlberg

In vivo bioluminescence imaging reveals differences in Leishmania infantum parasite killing kinetics by antileishmanial reference drugs

Source
ACS Infectious Diseases - ISSN 2373-8227-10:6 (2024) p. 2101-2107
Author(s)

Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids

Source
Nature communications - ISSN 2041-1723-15:1 (2024) p. 1-18
Author(s)
    Benoit Stijlemans, Patrick De Baetselier, Inge Van Molle, Laurence Lecordier, Erika Hendrickx, Ema Romão, Cécile Vincke, Wendy Baetens, Steve Schoonooghe, Gholamreza Hassanzadeh-Ghassabeh, Hannelie Korf, Marie Wallays, Joar E. Pinto Torres, David Perez-Morga, Lea Brys, Oscar Campetella, María S. Leguizamón, Mathieu Claes, Sarah Hendrickx, Dorien Mabille, Guy Caljon, Han Remaut, Kim Roelants, Stefan Magez, Jo A. Van Ginderachter, Carl De Trez

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc₁

Source
Science translational medicine - ISSN 1946-6234-15:726 (2023) p.
Author(s)
    Stéphanie Braillard, Martine Keenan, Karen J. Breese, Jacob Heppell, Michael Abbott, Rafiqul Islam, David M. Shackleford, Kasiram Katneni, Elly Crighton, Gong Chen, Rahul Patil, Given Lee, Karen L. White, Sandra Carvalho, Richard J. Wall, Giulia Chemi, Fabio Zuccotto, Silvia González, Maria Marco, Julianna Deakyne, David Standing, Gino Brunori, Jonathan J. Lyon, Pablo Castañeda-Casado, Isabel Camino, Maria S. Martinez Martinez, Bilal Zulfiqar, Vicky M. Avery, Pim-Bart Feijens, Natascha Van Pelt, An Matheeussen, Sarah Hendrickx, Louis Maes, Guy Caljon, Vanessa Yardley, Susan Wyllie, Susan A. Charman, Eric Chatelain