Abstract
Our gut microbiome is affected by many factors, and it seems (prescribed) drug use is one of the most important factors affecting its' composition and function. The first years of life are crucial for the acquisition of a healthy and stable gut microbiome, yet infancy is also when we use most antibiotics. Young infants may also receive gastric acid inhibitors for gastro-oesophageal reflux symptoms although efficacy and safety have been questioned. As antibiotics and gastric acid inhibitors are known to disrupt the gut microbiome in adults, these could even have larger and long-lasting effects on the microbiome and health of young children. With these projects, we want to contribute to mapping antibiotics and protonpump utilisation during early childhood – to assess the potential extent of overconsumption. We also want to explore drug-microbiome interactions in young children, and the potential bi-directional effect on infections. These projects might have direct clinical implications, by contributing to improved prescription practices and reducing inappropriate intake.
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