Support maintenance scientific equipment.
Structure-activity relationship investigation in correlation with bioavailability of proanthocyanidins as nutritional antioxidants.
Abstract
Researcher(s)
- Promoter: Vlietinck Arnold
- Co-promoter: De Bruyne Tess
- Co-promoter: Vanden Berghe Dirk
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: De Bruyne Tess
- Promoter: Deelstra Hendrik
- Fellow: Bosscher Douwina
Research team(s)
Project type(s)
- Research Project
High pressure liquid chromatographic techniques with fluorimetric detection for the evaluation of antioxidative parameters in vivo and structure-activity assessment of antioxidative natural products.
Abstract
This project covers the assessment of the in vivo antioxidative properties of natural products. In a first step, rats are stressed with CCl4, after which the concentration of free malondialdehyde and related hydroxyalkenals, determined by means of HPLC, of stressed laboratory animals is compared to the normal, basal concentration. The use of fluorimetric detection enhances both sensitivity and selectivity of the method substantially, important parameters when using small laboratory animals with low MDA plasma concentrations. Subsequently, the in vivo antioxidative effect of some selected polyphenols will be determined, with emphasis on flavonoids and proanthocyanidins. For those compounds structure-activity relationships for in vivo inhibition of lipid peroxidation will be investigated.Researcher(s)
- Promoter: De Bruyne Tess
Research team(s)
Project type(s)
- Research Project
Structure elucidation of biologically active natural products as prototypes for new drugs.
Abstract
Biologically active natural products from higher plants are isolated and identified, to serve as prototypes for potential new drugs.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Bruyne Tess
Research team(s)
Project type(s)
- Research Project
Structure elucidation of biologically active natural products as prototypes for new drugs.
Abstract
Biologically active natural products from higher plants are isolated and identified, to serve as prototypes for potential new drugs.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Bruyne Tess
Research team(s)
Project type(s)
- Research Project
Chromatographic and structural investigations of ì chemotherapeutically active plant phenolicsì
Abstract
The structure of chemotherapeutically active plant condensed tannins viz. dimeric and trimeric procyanidines of the A, B and C-series will be determined by means of two dimensional nuclear magnetic resonance (2-D-NMR) spectrometryResearcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Bruyne Tess
Research team(s)
Project type(s)
- Research Project
Chromatographic and structural investigations of ì chemotherapeutically active plant phenolicsì
Abstract
The structure of chemotherapeutically active plant condensed tannins viz. dimeric and trimeric procyanidines of the A, B and C-series will be determined by means of two dimensional nuclear magnetic resonance (2-D-NMR) spectrometryResearcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Bruyne Tess
Research team(s)
Project type(s)
- Research Project