The fast-dissociating D₂ antagonist antipsychotic JNJ-37822681 is a neuronal Kv7 channel opener : potential repurposing for epilepsy treatment

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British journal of pharmacology - ISSN 0007-1188- (2025) p.
Auteur(s)
    Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Mark Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela

Potassium current inactivation as a novel pathomechanism for KCNQ2 developmental and epileptic encephalopathy

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Epilepsia - ISSN 0013-9580-66:6 (2025) p. e98-e105
Auteur(s)
    Ingride Luzio Gaspar, Gaetano Terrone, Giusy Carleo, Lidia Carotenuto, Francesco Miceli, Gabriella De Vita, Maurizio Taglialatela

In silico assisted identification, synthesis, and In vitro pharmacological characterization of potent and selective blockers of the epilepsy-associated KCNT1 channel

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Journal of medicinal chemistry - ISSN 0022-2623-67:11 (2024) p. 9124-9149
Auteur(s)
    Nunzio Iraci, Lidia Carotenuto, Tania Ciaglia, Giorgio Belperio, Francesca Di Matteo, Ilaria Mosca, Giusy Carleo, Manuela Giovanna Basilicata, Paolo Ambrosino, Rita Turcio, Deborah Puzo, Giacomo Pepe, Isabel Gomez-Monterrey, Maria Virginia Soldovieri, Veronica Di Sarno, Pietro Campiglia, Francesco Miceli, Alessia Bertamino, Carmine Ostacolo, Maurizio Taglialatela

Kv7 channel activation reduces brain endothelial cell permeability and prevents kainic acid-induced blood-brain barrier damage

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American journal of physiology : cell physiology - ISSN 0363-6143-326:3 (2024) p. C893-C904
Auteur(s)
    Camilla Celentano, Lidia Carotenuto, Francesco Miceli, Giusy Carleo, Brunella Corrado, Giulia Baroli, Stefania Iervolino, Raffaele Vecchione, Maurizio Taglialatela, Vincenzo Barrese