Research team
Expertise
From beginning of my research career to till date, I studied the novel combination strategies for the treatment of solid tumors. In particular, my research focuses on repurposing of existing non-cancer drugs for the use in combination with known anti-cancer targeted therapies. To support these research goals, I am using a tumor and healthy three-dimensional tissue engineering techniques (culture of spheroid, organoid and CAM assay) as a state-of-the-art pre-clinical model and implementing novel live-cell imaging techniques for real-time analysis of biological events in response to oxidative-stress therapy. Moreover, to support my experimental results, I also used computer simulations techniques (Classical molecular Dynamics and molecular Docking) to understand the underlying mechanism of experimental data with nanoscale precision. Specifically, I studied the action of extracellular reactive oxygen and nitrogen species (RONS) generated from medical device (such as Cold atmospheric plasma (CAP)) on cancer treatment and cell stimulation. I found that exogenous source of RONS enhances the intracellular RONS level of biological cells and the media during treatment, which leads to cancer cell death in skin melanoma (A375), breast cancer (MCF7), pancreatic cancer cells (PANC-1 and BXPC3) and glioblastoma (U251, LN18, LN229, U87-MG and T98G) cells through the activation of redox signaling.