Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease

Source
Molecular neurodegeneration - ISSN 1750-1326-19:1 (2024) p. 1-25
Author(s)

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology

Source
Nature neuroscience - ISSN 1097-6256- (2024) p. 1-39
Author(s)

The y-secretase substrate proteome and its role in cell signaling regulation

Source
Molecular cell - ISSN 1097-2765-83:22 (2023) p. 4106-4122.e10
Author(s)
    Pengfei Hou, Magdalena Zielonka, Lutgarde Serneels, Anna Martinez-Muriana, Nicola Fattorelli, Leen Wolfs, Suresh Poovathingal, Dries T'Syen, Sriram Balusu, Tom Theys, Mark Fiers, Renzo Mancuso, Andrew J.M. Howden, Bart De Strooper

A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons

Source
Acta neuropathologica communications - ISSN 2051-5960-11:1 (2023) p. 1-22
Author(s)
    Jimmy Beckers, Arun Kumar Tharkeshwar, Laura Fumagalli, Matilde Contardo, Evelien Van Schoor, Raheem Fazal, Dietmar Rudolf Thal, Siddharthan Chandran, Renzo Mancuso, Ludo Van Den Bosch, Philip Van Damme